Vol. 19 No. 1s: Psycho-Oncology Research in China

Featured Article

Article ID: 4561

A univariate and multivariate Mendelian randomization study of the causal association of arterial stiffness with bone mineral density and osteoporosis

by Bowen Hong, Shaoshuo Li, Yi Zhou, Jiapeng Ye, Mao Wu, Yang Shao, Jianwei Wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

This investigation employed Mendelian randomization (MR) analysis to explore the causal associations of arterial stiffness with bone loss or osteoporosis. Genetic instruments for arterial stiffness index (ASI) were identified in previous genome-wide association studies, with single-nucleotide polymorphisms (SNPs) subjected to rigorous selection criteria. The causal links between ASI and osteoporosis and bone mineral density (BMD) (femoral neck, forearm, lumbar spine) were examined using the inverse variance weighted (IVW) method. Leave-one-out (for SNPs) and reverse MR analyses were also performed. An increased ASI was causally related to a decreased forearm BMD risk (IVW method; odds ratio [OR] = 0.593, 95% confidence interval [CI]: 0.408–0.862); no other causal links were identified. The multivariate MR analyses confirmed persistent links between ASI and forearm BMD after adjusting for body mass index (OR = 0.551, 95% CI: 0.309–0.983) or type 2 diabetes mellitus (OR = 0.690, 95% CI: 0.547–0.872). The reverse MR analysis identified no significant effects of BMD or osteoporosis on ASI. Overall, increased ASI was causally associated with reduced forearm BMD.

Featured Article

Article ID: 4296

The Impact of Chronic Obstructive Pulmonary Disease on Respiratory Physiology, Chemotherapy Tolerance, and Psychological Adaptation in Oncology Patients: A Multidimensional Analysis

by Hui Wei

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract Chronic obstructive pulmonary disease (COPD) exacerbates clinical outcomes in oncology patients through impaired respiratory mechanics, chemoresistance, and psychological distress. This review examines: (1) COPD-mediated alterations in lung function and gas exchange during cancer therapy; (2) Mechanistic links between COPD inflammation and chemotherapeutic efficacy; (3) Psychosocial interventions improving treatment adherence and quality of life. Data from randomized controlled trials (RCTs) and longitudinal cohort studies demonstrate that integrated cognitive-behavioral therapy (CBT) reduces anxiety by 35% compared to standard care (95% CI: 28-42%, p<0.001). (5) Comprehensive management strategies combining pulmonary rehabilitation and psychotherapy show 22% higher 5-year survival rates in COPD-positive cancer patients (HR: 0.78, 95% CI: 0.65-0.93). (7)