Vol. 19 No. 1s: Psycho-Oncology Research in China

Featured Article

Article ID: 4561

A univariate and multivariate Mendelian randomization study of the causal association of arterial stiffness with bone mineral density and osteoporosis

by Bowen Hong, Shaoshuo Li, Yi Zhou, Jiapeng Ye, Mao Wu, Yang Shao, Jianwei Wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

This investigation employed Mendelian randomization (MR) analysis to explore the causal associations of arterial stiffness with bone loss or osteoporosis. Genetic instruments for arterial stiffness index (ASI) were identified in previous genome-wide association studies, with single-nucleotide polymorphisms (SNPs) subjected to rigorous selection criteria. The causal links between ASI and osteoporosis and bone mineral density (BMD) (femoral neck, forearm, lumbar spine) were examined using the inverse variance weighted (IVW) method. Leave-one-out (for SNPs) and reverse MR analyses were also performed. An increased ASI was causally related to a decreased forearm BMD risk (IVW method; odds ratio [OR] = 0.593, 95% confidence interval [CI]: 0.408–0.862); no other causal links were identified. The multivariate MR analyses confirmed persistent links between ASI and forearm BMD after adjusting for body mass index (OR = 0.551, 95% CI: 0.309–0.983) or type 2 diabetes mellitus (OR = 0.690, 95% CI: 0.547–0.872). The reverse MR analysis identified no significant effects of BMD or osteoporosis on ASI. Overall, increased ASI was causally associated with reduced forearm BMD.

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Article ID: 4562

Enhanced external counterpulsation on exercise tolerance in pneumoconiosis: Insights from comorbidity subgroups efficacy and predictors

by Zhenhui Qin, Weimin Xie, Ning Zhu, Xijuan Lin, Tingting Deng, Ting Xu

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background: To investigate the efficacy of enhanced external counterpulsation (EECP) in improving exercise tolerance in patients with pneumoconiosis, focusing on differences in efficacy with and without lung disease comorbidities, and to identify key predictors of EECP efficacy. Patients and methods: Seventy patients with occupational pneumoconiosis were enrolled in a single-center randomized controlled trial, and were randomly divided into the conventional group (35 patients) and the EECP group (35 patients), and according to the presence or absence of lung disease comorbidities, subjects were divided into the subgroups with and without comorbidities. The conventional group received health management, medication, and individualized exercise prescription, while the EECP group received 1 h of EECP intervention per day for 5 weeks on top of the conventional treatment. Exercise tolerance indexes before and after treatment were assessed by cardiopulmonary exercise test (CPET), including AT-VO 2 Kg, Max-VO 2 Kg, AT-O 2 puls, Max-O 2 puls, AT-Load, AT-Mets and Max-Mets 7 indicators. Predictors of efficacy were analyzed by univariate and multivariate linear regression using post-treatment AT-VO 2 Kg as the main dependent variable. Results: Comparison of all CPETs between the EECP and non-EECP groups, and the comorbidity subgroup and the uncomplicated subgroup before treatment showed no statistically significant difference ( P > 0.05), and the post-treatment AT-VO 2 Kg, Max-VO 2 Kg, AT-O 2 puls, Max-O 2 puls, and metabolic equivalents of the EECP group and the uncomplicated subgroup (AT-Mets, Max-Mets) were significantly improved compared with the control group (all P < 0.05), but no significant benefit was seen in the comorbidity subgroup ( P > 0.05). Multiple regression analysis showed that comorbidity was a negative predictor of efficacy whereas pre-treatment AT-VO 2 Kg was a positive predictor. No safety adverse events occurred in either group. Conclusion: EECP safely and effectively improved exercise tolerance in patients with pneumoconiosis, and its efficacy was particularly significant in the comorbidity-free subgroup. The comorbidity subgroup failed to benefit significantly from the EECP intervention, and further analysis showed that comorbidity was an independent negative predictor limiting the treatment effect. In addition, pretreatment AT-VO 2 Kg served as a positive predictor of efficacy, suggesting that patients with higher baseline cardiorespiratory reserve had a superior benefit from EECP treatment.

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Article ID: 4563

Low-dose TLR9 agonist ODN 2395 drives microglial neuroprotective activation by CREB phosphorylation

by Ziqi Han, Li Xiang, Yuanling Mao, Zhigang Zhu, Yubao Wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background: The Toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine (CpG) oligodeoxynucleotide (ODN) has been reported to induce microglial pro-inflammatory polarization, contributing to neuronal damage. This study investigates the anti-inflammatory activation of microglia by low-dose CpG ODN 2395 and its underlying mechanism. Methods and Results: BV2 microglia, primary mouse mixed glial cultures, and primary mouse mesencephalic neuron-glial cultures were treated with ODN 2395. RT-qPCR, ELISA, Western blotting, and immunocytochemistry were employed. Lipopolysaccharide (LPS) was used to induce neurotoxicity and serve as a control to compare inflammatory responses. Low-dose ODN 2395 (100–200 nM) causes minimal mitochondrial ROS production and promotes anti-inflammatory polarization in microglia, characterized by high levels of Arginase 1 (Arg1), IL-10, and brain-derived neurotrophic factor (BDNF), but low expression of iNOS, TNF-α, and IL-1β. Phosphorylated cAMP response element-binding protein (CREB) is essential for the induction of anti-inflammatory and neuroprotective factors by ODN 2395. Even with endoplasmic reticulum stress, a common pathology in neuroinflammatory disorders, low-dose ODN 2395-activated microglia hardly release mature IL-1β, partially due to defective NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) priming. NLRP3 knockout validated its crucial role in microglial mature IL-1β release. In neuron-glial cultures, low-dose ODN 2395 significantly mitigated LPS-induced neurotoxicity, evidenced by preserved neurons and reduced reactive microgliosis. Conclusions: Our findings provide novel insights into the immune responses of microglial TLR9 activation and suggest stimulatory intensity of TLR9 as a potential determinant for the immunotherapeutic strategy.

Featured Article

Article ID: 4565

Tissue engineering-based strategies of prevention and treatment for esophageal stenosis after endoscopic submucosal dissection

by Fan Yang, Xiangyu Kong

Psycho-Oncologie , Vol.19, No.1s, 2025;

Due to lower trauma and higher resection rate, endoscopic submucosal dissection (ESD) has become the preferred therapy for early esophageal cancer. Esophageal stenosis is a common complication after ESD. A variety of methods are currently used to prevent and treat this complication, including oral administration or local injection of steroid hormones, balloon dilation, and stent implantation, but none are satisfactory when lesions exceed 3/4 of the esophageal circumference. With the development of tissue engineering and regenerative medicine, various biomaterials, including synthetic materials and natural materials, have been widely used and applied in wound healing and tissue regeneration. This review summarizes advancements in tissue engineering and regenerative medicine in wound repair, and focuses on the contribution of biomaterials in the prevention and treatment of esophageal stenosis after ESD to provide reference for exploring better strategies in clinical practice.

Featured Article

Article ID: 4569

Comparison of the efficacy of photodynamic therapy and LEEP in the treatment of cervical intraepithelial neoplasia grade 2

by Xiaofang Liu, Qiming Qu, Jiahui Lv, Hongfang Wang, Jingxuan Li, Jinghui Jia

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To investigate the therapeutic effect of 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) on cervical intraepithelial neoplasia 2 (CIN2) and the clearance effect of high risk human papiloma virus (HRHPV). papillomavirus (high risk human papiloma virus, HRHPV) clearance effect. Methods: Patients treated for high-grade cervical intraepithelial lesions, HSIL/CIN2 from February 2018 to February 2023 in the Department of Obstetrics and Gynecology at the Air Force Specialty Medical Center were collected. Patients with CIN2 who met the eligibility criteria for enrollment were included and divided into a treatment group (ALA-PDT) and a control group (LEEP) in a 1:1 ratio, using a non-inferiority, single-center, open-blind, controlled clinical study method. Results: There were 96 people in the treatment group, of whom 91 were treated effectively. In the control group, 107 people were treated, of whom 104 were effective. The effective rate of the control group was 97.20%, and the effective rate of the treatment group was 95.83%, and the difference was not statistically significant ( P > 0.05). The risk ratio was 0.986 (95%–102%). Difference between the two groups: −1.36% (−5.77%, 3.05%), based on the lower limit of the confidence interval being greater than Δ, i.e., −10%. Therefore, the treatment group was non-inferior to the control group. Conclusion: ALA-PDT is an effective and safe noninvasive treatment for patients with cervical HSIL/CIN2. It not only effectively removes diseased tissue and HR-HPV, but also preserves the intact tissue structure of the cervix, and can be used as a therapeutic approach for sick women of reproductive age and patients who wish to observe treatment, which may reduce nonessential surgery.

Featured Article

Article ID: 4570

The impact of air pollutant exposure on diabetes hospital admissions in a city of Xinjiang

by Zhicong Fu, Haoxuan Gong, Xiaopeng Hu, Yuting Xie, Dongsheng Rui

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To explore the influence of air pollution on the daily hospitalization admissions of diabetic patients in a certain city of Xinjiang and the differences among the population, providing a reference basis for formulating prevention and control policies for diabetes in response to air pollution in the future. Methods: Daily hospitalization admissions of 10 comprehensive hospitals in a certain city of Xinjiang from 2021 to 2022 were collected, along with air pollutants and meteorological monitoring data during the same period. The relationship between air pollutant concentrations and the daily hospital admission rates of diabetes patients was analyzed using a distribution lag nonlinear model. Results: There was no statistically significant difference in the impact of PM 2.5 and PM 10 exposure on daily hospital admission rates, with RR values reaching peak values at lag5, lag0, as follows: 1.06 (95% CI: 1.00, 1.12), 1.08 (95% CI: 1.00, 1.16); NO, SO 2 , O 3 , and CO affected the daily hospital admission rate of diabetes patients, with RR values reaching peak values at lag6, lag1, lag2, and lag5 days, respectively, as follows: 1.21 (95% CI: 1.11, 1.31), 1.69 (95% CI: 1.43, 1.99), 1.23 (95% CI: 1.14, 1.34), 1.36 (95% CI: 1.21, 1.53). PM2.5 had no statistically significant impact on the daily hospital admission rates of each subpopulation; PM10 had an immediate effect only on the daily hospital admission rate of males, reaching a peak at lag0 day at 1.16 (95% CI: 1.05, 1.28); NO 2 had the largest RR values for the daily hospital admission rates of males and those under 65 years of age, respectively, at 1.22 (95% CI: 1.09, 1.35) and 1.19 (95% CI: 1.08, 1.32); the largest RR values for females and those over 65 years of age were 1.26 (95% CI: 1.11, 1.44) and 1.23 (95% CI: 1.07, 1.41), respectively, and these were statistically significant. SO 3 and O 3 showed an increasing trend in the daily hospital admission rates of each subpopulation before decreasing, with peaks appearing in lag1–lag3, which were statistically significant. Conclusion: Exposure to NO 2 , SO 2 , O 3 , and CO increased the risk of hospitalization for diabetes. The diabetic population of women and those over 65 years of age were more vulnerable to exposure to NO 2 and CO, resulting in an increased hospitalization risk. During the entire day and the period from 9 to 21 h, the trend of the influence of NO 2 on the daily hospitalization admission of diabetic patients varies the most, while there is no obvious change trend for the other pollutants.

Featured Article

Article ID: 4573

A machine learning predictive model based on conventional two-dimensional echocardiography and serum biomarkers for early detection of ascending aorta dilation in BAV patients

by Xingyu Long, Yunxia Niu, Guixuan Nie, Sijing He, Lisha Na

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To compare echocardiographic parameters and lipid biomarker levels between patients with bicuspid aortic valve (BAV) associated with ascending aorta dilation and those without dilation using machine learning models, and to identify early diagnostic features for BAV-associated dilation. Methods: A retrospective cohort of 51 BAV patients (25 with ascending aorta dilation and 26 without) from the Ningxia Medical University Affiliated Hospital (January 2024–November 2024) was enrolled. Routine echocardiography and lipid profile measurements were performed. Lasso regression was applied to select key features, construct a predictive model, and develop a nomogram for individualized risk assessment. Results: BAV dilation group exhibited significantly higher AAoV and AAoMPG than the non-dilation group ( P < 0.05 for both). HDL levels were also elevated in the dilation group ( P < 0.05). Lasso regression identified five critical features: age, HDL, ApoB, LVMI, and AAoV, with the model formula: Y = −0.02678133 + (0.10741491 × age) + (0.25612267 × HDL) + (−0.12903915 × ApoB) + (0.14253473 × LVMI) + (0.49063628 × AAoV). The model achieved an AUC of 0.825 (95% CI: 0.694–0.933). Conclusion: This study successfully identified key features using Lasso regression and developed an efficient predictive model for BAV-associated ascending aorta dilation. The model demonstrates strong diagnostic performance, interpretability, and clinical applicability. The nomogram provides a practical tool for individualized risk prediction, aiding early diagnosis, intervention decisions, and patient follow-up.

Featured Article

Article ID: 4571

Inhibition of MTERF4 disrupts mitochondrial function and attenuates amyloidogenic APP processing via HSDL2-mediated apoptosis and autophagy

by Zijun Cao, Xue Feng, Li Wang, Xiaoliang Wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abnormal proteolytic cleavage events and mitochondrial dysfunction are implicated in the neuropathology of Alzheimer’s disease (AD). Mitochondrial transcription factor 4 (MTERF4) is essential for mitochondrial ribosome assembly and translational regulation. In this study, we investigated the role of MTERF4 in mitochondrial dysfunction and amyloid precursor protein (APP) processing. MTERF4 knockdown (KD) significantly reduced adenosine triphosphate (ATP) production, mitochondrial DNA (mtDNA) copy number, and mitochondrial membrane potential (MMP) in HEK293-APPswe cells. To uncover the fundamental mechanisms, RNA sequencing (RNA-seq) analysis was conducted to screen for differentially expressed genes (DEGs). Notably, we demonstrated an upregulation of Hydroxysteroid dehydrogenase-like protein 2 (HSDL2), consistent with RNA-seq analysis, which has been implicated in apoptosis and autophagy regulation. Flow cytometry (FCM) analysis demonstrated that MTERF4 KD significantly reduced apoptosis, and subsequent experimental validation revealed that this effect was mediated via the Bcl-2/Bax/Caspase-3 pathway. Furthermore, MTERF4 KD notably raised the protein levels of Beclin-1 and ATG5, elevated the LC3Ⅱ/LC3Ⅰ ratio, and decreased P62 protein expression, thereby promoting autophagy. Additionally, MTERF4 KD resulted in reduced levels of APP, ADAM10, and secreted Aβ42. Moreover, MTERF4 KD reduced both α- and β-cleavage of APP. In conclusion, our study highlights the crucial role of MTERF4 in mitochondrial dysfunction and its regulatory effect on HSDL2 expression in HEK293-APPswe cells. MTERF4 inhibition suppresses apoptosis via the Bcl-2/Bax/Caspase-3 pathway and attenuates APP processing by enhancing autophagy. These findings indicate that MTERF4 is critically involved in AD pathogenesis and may serve as a potential therapeutic target.

Featured Article

Article ID: 4574

Expression and diagnostic value of peripheral blood miRNA-125b and miRNA-144 in patients with gestational diabetes mellitus

by Yanying Wu, Lijie Shen, Xin Zhang, Fengzhen Guo

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: This study aimed to investigate the aberrant miRNA expression profiles in the peripheral blood of pregnant women and evaluate their potential diagnostic utility in gestational diabetes mellitus (GDM). Methods: A cohort of 62 pregnant women diagnosed with GDM (GDM group) and 62 pregnant women with normal glucose tolerance (control group) were enrolled. Peripheral blood samples were collected during late pregnancy (26–40 weeks gestation). Next-generation sequencing was employed to identify differentially expressed miRNAs, followed by validation through reverse transcription polymerase chain reaction (RT-PCR). Statistical analyses were conducted to examine the correlation between miRNA expression levels and clinical parameters, as well as their contribution to GDM risk. Results: A total of 157 differentially expressed miRNAs were identified in the GDM group, with 114 upregulated and 43 downregulated compared to the control group. Hierarchical clustering analysis revealed distinct miRNA expression patterns between the two groups, with 8 miRNAs significantly upregulated and 6 significantly downregulated. qPCR validation of miRNAs associated with energy metabolism confirmed that the expression levels of miRNA-125b, miRNA-543, and miRNA-144 were consistent with the sequencing data. Clinical parameters including pre-pregnancy weight, body mass index (BMI), pre-delivery diastolic blood pressure, and platelet count were significantly higher in the GDM group compared to controls. In GDM patients, miRNA-125b expression was significantly reduced (P < 0.001), while miRNA-144 expression was significantly increased ( P < 0.001) compared to non-GDM pregnant women. Multivariate analysis identified miRNA-125b, miRNA-144, and pre-pregnancy BMI as independent risk factors for the development of GDM ( P < 0.05). Conclusion: Dysregulated expression of miRNA-125b and miRNA-144 in peripheral blood may serve as valuable biomarkers for the early diagnosis of gestational diabetes mellitus.

Featured Article

Article ID: 4575

Construction and evaluation of a short-term prognostic model for acute ischemic stroke in emergency settings

by Na Chen, Junbo Wang, Yuxin Liu, Lijing Zhao

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To develop a prediction model for 14-day poor prognosis in acute ischemic stroke (AIS) patients in emergency settings and evaluate its predictive accuracy. Methods: We conducted a prospective cohort study, enrolling AIS patients admitted to our hospital between October 2018 and December 2020, within 72 h of symptom onset. Univariate and multivariate logistic regression analyses were performed to identify factors associated with poor prognosis. Receiver operating characteristic (ROC) curves were used to determine cutoff values for continuous variables, which were subsequently discretized based on clinical relevance. A clinical scoring model for short-term prognosis was constructed using the β coefficients of selected variables. AIS patients admitted between January and December 2021 served as the internal validation cohort to assess the model’s performance. Results: A total of 321 patients were included, with 223 in the training cohort and 98 in the validation cohort. Multivariate logistic regression identified age, high-sensitivity C-reactive protein(hs-CRP), prealbumin (PA), infarct volume, Frailty Screening Questionnaire (FSQ), and National Institutes of Health Stroke Scale (NIHSS) scores as independent predictors of poor short-term prognosis. The prognostic scoring system, with a total score of 15, included the following components: age ≥ 74 years (1 point), PA ≤ 373 mg/L (2 points), large-artery atherosclerosis (1 point), cardioembolic stroke (2 points), infarct volume ≥ 2.18 cm 3 (2 points), FSQ score ≥ 3 (1 point), and NIHSS score ≥ 4 (6 points). The area under the ROC curve (AUC) for predicting poor prognosis was 0.927 (95%CI: 0.894~0.960), with an optimal cutoff score of ≥5 points, yielding a sensitivity of 0.770 and specificity of 0.976. The model’s performance in the validation cohort was consistent, with an AUC of 0.892 (95%CI: 0.827~0.957). Conclusion: The short-term prognostic scoring system for AIS demonstrated strong diagnostic accuracy and offers valuable guidance for clinicians in early prognosis assessment in emergency settings.

Featured Article

Article ID: 4576

Clinical efficacy and safety evaluation of immune checkpoint inhibitors combined with chemoradiotherapy in the treatment of advanced cervical cancer: An 80-case prospective cohort study

by Cuili Niu, Xiuyin Gui, Shuqing Tian

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To investigate the clinical efficacy and safety of immune checkpoint inhibitors combined with chemoradiotherapy in the treatment of advanced cervical cancer. Methods: A total of 80 patients with advanced cervical cancer admitted to our hospital from January 2022 to December 2023 were randomly divided into a combination therapy group (pembrolizumab + chemoradiotherapy, 40 cases) and a control group (chemoradiotherapy alone, 40 cases). The objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and adverse reactions were compared between the two groups. Results: The ORR of the combination therapy group was 75.0% (30/40), significantly higher than 55.0% (22/40) in the control group ( P = 0.043). The median PFS was 12.5 months vs. 9.0 months ( P = 0.022), and the median OS was 24.0 months vs. 18.0 months ( P = 0.027). There was no significant difference in the incidence of grade 3 and above adverse reactions between the two groups (40.0% vs. 35.0%, P = 0.546), but immune-related adverse reactions in the combination therapy group (such as hypothyroidism 12.5%, rash 10.0%) were more common, mostly grade 1–2. Conclusion: Immune checkpoint inhibitors combined with chemoradiotherapy can improve the efficacy of advanced cervical cancer, prolong survival, and have controllable safety, providing a new treatment option for patients.

Featured Article

Article ID: 4578

Comparison between laparoscopic radical hysterectomy and traditional open surgery in the treatment of early cervical cancer: A 100-case randomized controlled study on postoperative quality of life and complications

by Ling Zhang, Suhui Ma, Xiaoqian Wang, Tao Yan

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To compare the postoperative quality of life (QOL) and complication rates between laparoscopic radical hysterectomy (LRH) and traditional open hysterectomy (OH) in the treatment of early cervical cancer. Methods: From January 2020 to December 2023, 100 patients with stage ⅠA2-ⅡA1 cervical cancer were randomized into LRH group (50 cases) and OH group (50 cases). Surgical indicators, complications, 6-month QOL (FACT-C score), and 2-year disease-free survival (DFS) were compared. Results: The LRH group showed significantly better outcomes in intraoperative blood loss (150 ± 30 mL vs. 280 ± 50 mL, P < 0.01) and postoperative hospital stay (5.2 ± 1.3 days vs. 7.8 ± 1.5 days, P < 0.01) than the OH group. There was no significant difference in total complication rates (16.0% vs. 14.0%, P = 0.721), but the LRH group had a lower wound infection rate (2.0% vs. 8.0%, P = 0.043). The LRH group also demonstrated superior 6-month FACT-C scores (86.5 ± 8.2 vs. 80.3 ± 7.5, P = 0.002) and 2-year DFS (92.0% vs. 88.0%, P = 0.345), though the DFS difference was not statistically significant. Conclusion: LRH is safe and feasible for early cervical cancer, improving postoperative QOL and reducing wound complications, with comparable long-term survival outcomes to OH.

Featured Article

Article ID: 4579

Nomogram for predicting cognitive impairment in postpartum depression patients after pharmacotherapy: Development and validation

by Jing Chai, Ye Di, Jingjing Cui, Longjie Yuan, Baibai Wang, Luobin Ding

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To develop and validate a clinical feature-based nomogram for predicting the risk of significant cognitive impairment in postpartum depression (PPD) patients treated with selective serotonin reuptake inhibitors (SSRIs). Methods: A retrospective study was conducted on 350 PPD patients treated with SSRI monotherapy at our institution between January 2020 and December 2024. Cognitive function was assessed at week 8 using the Montreal Cognitive Assessment (MoCA), with MoCA < 26 defined as significant cognitive impairment. Predictors were screened using LASSO regression, and a multivariate logistic regression model was built to construct the nomogram. Internal validation was performed via bootstrapping (1000 repetitions). Model discrimination, calibration, and clinical utility were evaluated using the C-statistic, calibration curve, and decision curve analysis (DCA). Results: Six predictors were identified: age, baseline depression severity (HAMD-17 score), years of education, SSRI type (paroxetine vs. others), baseline sleep quality (PSQI score), and postpartum duration. The model exhibited a C-statistic of 0.82 (95% CI: 0.78–0.86). The calibration curve demonstrated good agreement between predicted and actual risks. DCA indicated significant clinical net benefit across a wide threshold probability range (0.1–0.6). Conclusion: This nomogram effectively predicts individualized risk of significant cognitive impairment in SSRI-treated PPD patients, demonstrating good discrimination, calibration, and clinical utility. It serves as a valuable tool to aid clinical decision-making.

Featured Article

Article ID: 4585

The effect of ivabradine tablets combined with milrinone on arterial blood flow and cTnI in patients with acute myocardial infarction combined with heart failure

by Kejing Zhou, Bihua Wu

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To investigate the effects of ivabradine tablets combined with milrinone on arterial blood flow and cTnI in patients with acute myocardial infarction (AMI) combined with heart failure (HF). Methods: A randomised double-blind, placebo-parallel controlled clinical study protocol was adopted to select 78 patients with AMI combined with HF who attended the cardiology care unit of our hospital from January 2022 to January 2024, and randomly divided them into 2 groups of 39 patients each. Both groups were given conventional treatment, with Bmilrinone combined with placebo for oral administration in the control group and milrinone combined with ivabradine hydrochloride tablets for oral administration in the observation group. Compare the clinical efficacy and the occurrence of adverse reactions between the two groups. Compare the arterial blood flow indexes [cardiac index (CI), left ventricular ejection fraction (LVEF), global end-diastolic volume index (GEDVI), systemic vascular resistance index (SVRI), early diastolic/late diastolic LV valvular flow velocity (E/A ratio)], cardiac enzymology indexes [cardiac troponin I (cTnI), troponin T (cTnT)], and cardiac enzymes [cardiac troponin I (cTnI), troponin T (cTnT)] in the 2 groups before and after treatment, lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB)], circulating endocrine hormone levels [renin activity (PRA), angiotensin II (Ang II), aldosterone (Ald)] and quality of life scoring indexes [Seattle Angina Scale (SAQ), Pittsburgh Sleep Quality Index (PSQI)]. Results: After treatment, the total clinical effectiveness rate of the observation group (87.18%) was significantly higher than that of the control group (66.67%) ( P < 0.05). The CI, LVEF, E/A ratio and SAQ scores of the observation group were significantly higher than those of the control group, and the scores of GEDVI, SVRI, cTnI, cTnT, LDH, CK-MB, PRA, Ang II, Ald and PSQI were significantly lower than those of the control group, which were significantly different ( P < 0.05). There was no significant difference in the comparison of the incidence of adverse reactions between the 2 groups ( P > 0.05) The incidence of adverse reactions in the 2 groups was not significantly different ( P > 0.05). Conclusion: Ivabradine tablets combined with milrinone in the treatment of AMI combined with HF patients with significant efficacy, can effectively reduce myocardial injury, stabilise arterial haemodynamics, improve the cardiac function of the patients, and does not increase the adverse effects of drugs.

Featured Article

Article ID: 4586

Effect of preoperative biliary drainage on pancreaticoduodenectomy in patients with low-level malignant obstructive jaundice

by Jing Yu, Yong Peng

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To investigate the effect of preoperative biliary drainage (PBD) on outcomes of pancreaticoduodenectomy (PD) in patients with low-level malignant obstructive jaundice. Methods: A retrospective analysis was conducted on patients who underwent PD due to low-level malignant obstructive jaundice at the Affiliated Hospital of North Sichuan Medical College and Nanchong Central Hospital between 1 January 2021, and 30 August 2024. Eligible patients had total serum bilirubin levels ≥171 μmol/L at the time of admission. Based on whether PBD was performed prior to surgery, patients were categorized into the PBD group and the direct surgery group. In the PBD group, clinical indicators before drainage (at admission) and after drainage (preoperatively) were compared to assess the effectiveness of jaundice reduction. Perioperative outcomes were compared between the two groups. Additionally, Kaplan–Meier survival analysis was used to evaluate the effect of PBD on perioperative outcomes and postoperative survival. Results: In the drainage group, significant improvements were observed in total bilirubin, direct bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels after biliary drainage ( P < 0.05). There were no significant differences between the two groups in terms of operative time, intraoperative blood loss, postoperative ICU transfer, reoperation rate, length of postoperative hospital stay, incidence of major complications (pancreatic fistula, bile leak, hemorrhage, intra-abdominal infection, delayed gastric emptying), or 30-day mortality (all P > 0.05). However, significant differences were found in the total complication rate, preoperative preparation time, and total hospitalization costs (all P < 0.05). Postoperative survival did not differ significantly between the two groups ( P > 0.05). Conclusion: Preoperative biliary drainage can effectively improve liver function in patients with low-level malignant obstructive jaundice. It is associated with a reduced overall incidence of postoperative complications following PD. While PBD may have a potential positive impact on postoperative survival, further large-scale studies are warranted to validate these findings.

Featured Article

Article ID: 4702

Study on the therapeutic effect of cupping combined with antiviral therapy in children with herpetic angina and its impact on inflammatory factors

by xiaowei zhang, yaqing zhang, xiaoxia su, yinghui zhang, wenzhuo cui

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective : To explore the therapeutic effect of cupping combined with antiviral therapy in children with herpetic angina and its impact on inflammatory factors. Method: A total of 112 pediatric patients with herpetic angina from June 2020 to May 2022 were selected as the study subjects, and randomly divided into two groups with 56 patients in each group using a number table method. The control group received antiviral therapy, while the observation group received cupping therapy. After 2 weeks of treatment, the patient's efficacy was evaluated, and a 6-month outpatient follow-up was completed. The time of symptom disappearance, visual analogue pain (VAS) score, myocardial enzyme spectrum, inflammatory factors, treatment safety, and recurrence rate were compared between the two groups. Result: After 2 weeks of intervention, the levels of VAS and CK-MB in both groups were reduced; The disappearance time, VAS score, and CK-MB of herpes, fever, and pharyngodynia symptoms in the observation group were lower than those in the control group (P<0.05); After 2 weeks of intervention, inflammatory factors were reduced in both groups; Observation group IL-1 β、 CSF-1、TNF- α、 The CRP level was lower than that of the control group (P<0.05); There was no statistical difference in the incidence of fatigue, myalgia, nasal burning sensation, and dizziness and nausea between the two groups during the treatment period (P>0.05); The recurrence rate in the observation group was lower than that in the control group at 3 and 6 months of follow-up after 4 weeks of treatment (P<0.05). Conclusion: Cupping combined with antiviral therapy can shorten the time for symptoms to disappear in children with herpetic angina, help alleviate pain and myocardial damage, and lower the level of inflammatory factors. Moreover, this treatment plan does not increase the incidence of adverse reactions, and the long-term recurrence rate of patients at 3 to 6 months is low, which is worth promoting and applying.

Featured Article

Article ID: 4626

Preliminary study on the mechanism of L1CAM promoting invasion and metastasis of cervical cancer

by Suyi Yi, Minjian Wang, Yue Zeng, Wenting Wu, Jing Li

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的 探讨细胞粘附分子 L1 基因 （L1CAM） 在宫颈癌中的呈报特征及其对肿瘤细胞增殖、迁移、侵袭和凋亡的双向调控。 方法 使用定量聚合酶链反应 （qPCR） 检测宫颈癌细胞系 （HeLa、SiHa、C-33A） 和正常宫颈上皮细胞 （HcerEpic） 中 L1CAM 的 mRNA 表达水平，并使用 siRNA 敲低和质粒过表达技术调节 L1CAM 表达。结合 Western Blot （WB） 验证基因作效率，CCK-8 法侦察细胞增殖活力，Transwell 法评估迁移和侵袭能力，流式细胞术分析细胞凋亡率。 结果 L1CAM 在 Hela、C-33A 中的表达水平相对高于其他宫颈细胞系。经 siRNA 敲低 L1CAM 后，宫颈癌细胞的增殖、迁移和侵袭能力显著降低，细胞凋亡率显著增加。相反，L1CAM 的过表达显著增强细胞增殖、迁移和侵袭，同时抑制细胞凋亡。. 结论 L1CAM在宫颈癌中异常表达，具有双向调控致癌过程的潜力，通过增强增殖、迁移、侵袭和抑制细胞凋亡来促进肿瘤进展，靶向L1CAM可能为宫颈癌的治疗提供新的策略。

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Article ID: 4676

Value of Quantitative MRI Combined with Blood CTC in Predicting the Prognosis of Neoadjuvant Chemotherapy for Breast Cancer

by Chen Sun, Chen Lin, Xingfang Jiang, Qichao Lei

Psycho-Oncologie , Vol.19, No.1s, 2025;

摘要 目标 分析磁共振成像 （MRI） 联合循环肿瘤细胞 （CTC） 定量参数预测乳腺癌新辅助化疗 （NAC） 预后的价值。 方法 共选取 98 例最初诊断为乳腺癌并于 2022 年 1 月至 2024 年 1 月在医院接受 NAC 的患者。NAC 结束后 4 周评估 MRI，并在我院进行改良根治性手术。根据 RECIST 1.1 标准，将患者分为治疗有效组 （n=47） 和治疗无效组 （n=51）。比较两组治疗前后的体积转移常数 （K trans ） 、血管外细胞外间隙容积比 （V e ） 、速率常数 （K ep ） 和 CTC 阳性率。采用受试者工作特征下面积 （ROC） 曲线 （AUC） 表示预后值。 结果 98 例患者中，有效率 47 例，有效率为 47.96%。治疗后 K trans 、 K ep 和 CTC 阳性率低于治疗前 （ P <0.05），治疗有效组低于治疗无效组 （ P <0.05）。K trans 、 K ep 和 CTC 阳性率与 TNM 分期呈正相关 （ P <0.05）。CTC 阳性预测乳腺癌患者 NAC 疗效的 K trans 、 K ep 和 AUC 值分别为 0.717 、 0.785 和 0.656。联合预测的 AUC 为 0.847，大于单独预测。联合预测的敏感性和特异性分别为 67.65% 和 90.38%。 结论 MRI 和血液 CTC 的定量参数与临床分期密切相关。它们的组合可以有效地帮助预测乳腺癌患者 NAC 的预后。

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Article ID: 4706

A column chart study of cognitive deficits in postpartum depression patients following pharmacologic therapy

by jing Chai, Ye Di, Jingjing Cui, Longjie Yuan, Baibai Wang, Luobin Ding

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: to construct a column-line graph prediction model of cognitive impairment in postpartum depression patients treated with medication and evaluate its efficacy. Methods: 120 patients with postpartum depression admitted to our hospital between August 2023 and June 2024 were selected as the study subjects, and were categorized into 81 cases in the non-occurrence group and 39 cases in the occurrence group by MoCA score. After unifactorial and multifactorial logistic regression analyses, the influencing factors of cognitive impairment were screened out, and a column-line graphical model was constructed to assess their predictive efficacy. Results: The results of univariate analysis showed comparisons of literacy, intraoperative bleeding, alcohol consumption, smoking, SSRS score, DA, E1, E2, BDNF, 5-HT, PRL, FSH, and LH ( P <0.05), and multifactorial analysis showed that all of the above factors were risk factors for cognitive dysfunction, and the construction of the column-line diagram showed a significant efficacy with a sensitivity and accuracy of more than 80%. Conclusion: Column line plots predicted the risk of cognitive dysfunction after medication in patients with postpartum depression with significant efficacy.

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Article ID: 4671

Establishment and verification of prediction model on failure factors of radial arterial puncture in patients with heart failure

by Huan Wang, Jiangbo Zhang, Yinglong Meng, Min He

Psycho-Oncologie , Vol.19, No.1s, 2025;

A bstract ：   目的 ： 建立心力衰竭患者桡动脉穿刺失败因素的预测模型，并验证其有效性。 方法 ： 将 2019年7月至 2021年7月都江堰市中医院内科的 969 例患者，采用留一法 （LOO） 分为训练集 （n=700， 72.5%） 和验证集 （n= 269， 27.5%）。采用 Logistic 回归筛选心力衰竭患者桡动脉穿刺首针失败的危险因素，并建立相应的预测模型。绘制 ROC 曲线并验证模型的有效性。 结果 ： Logistic 回归分析显示，心率加快、呼吸急促、平均动脉压降低和血浆白蛋白降低是心力衰竭患者桡动脉穿刺失败的独立危险因素。桡动脉穿刺失败的概率计算为 8.010+0.025×心率+0.086×呼吸频率 -0.070× 表示动脉压-0.232×血浆白蛋白。ROC 曲线下面积 （AUC） 在训练集中为 0.823，在验证集中为 0.765。Hosmer-Lemeshow 检验表明，预测模型具有良好的稳定性。模型Jordan指数最大值为0.524，对应预测概率最优临界值为0.658，灵敏度为84.7%，特异度为67.8%。 结论 ： 基于回归分析的预测模型对心力衰竭患者桡动脉穿刺具有中等预测能力，可辅助临床决策，减轻患者疼痛，节省医疗耗材费用。

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Article ID: 4720

Prediction of clinical outcomes in elderly patients with hypertension combined with stroke based on CT imaging histology

by lin Dai, jie zhang, Haiyan zhang, Lin chen, Lin cao, Ling Guo, Yu wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To predict the clinical outcome of elderly patients with hypertension combined with stroke based on CT imaging histology. Methods : A total of 260 elderly patients with hypertension combined with stroke admitted during September 2023-January 2025 were analyzed and classified as poor (85) and good (175) by mRS score, clinical and imaging data were collected and compared, logistic regression analyzed the risk factors of patients, and R software constructed a column-line graph model to assess the model prediction efficacy with calibration, ROC, and decision curve with Consistency. Results :Logistic regression modeling analyzed uric acid, HCY, hyperlipidemia, diabetes mellitus, blood pressure variability, creatinine, black hole sign, shape irregularity, midline shift, and density inhomogeneity as risk factors influencing the occurrence of clinical outcomes in patients ( P <0.05);The Hosmer-Lemeshow goodness-of-fit test of the column-line graph model fit is high; the ROC curve analyzes the predictive efficacy of the column-line graph prediction model is good. Conclusion: CT imaging histology is effective in predicting patient clinical outcomes with high predictive efficacy.

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Article ID: 4666

Exploring the effect of Polygonatum cyrtonema polysaccharide DPC1 on D-galactose-induced mouse aging model based on AMPK/SIRT1 pathway

by 丝怡 zhang, teng, Yaosong, Guangzhen, Fei

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的： 阐明 黄精 多糖 （DPC1） 对 D-半乳糖 （D-gal） 诱导的氧化应激诱导小鼠衰老的改善机制，并研究其机制。设计：使用 D-gal （8 周时 0.12 g/kg） 诱导 ICR 小鼠同时管饲法施用 （0.15、0.30 或 0.60 g/kg） DPC1 建立了衰老模型。小鼠组织和血浆中抗氧化指数的测量。观察小鼠脑组织的病理变化。然后测定小鼠脑组织样本的线粒体三磷酸腺苷水平和线粒体膜电位。使用 Western blot 等分子生物技术研究 AMPK/SIRT1 信号通路和相关蛋白质。结果： 口服 DPC1 减轻了 D-gal 诱导的小鼠氧化损伤，如丙二醛 （MDA） 含量和单胺氧化酶 （毛） 活性水平降低，超氧化物歧化酶 （SOD） 、过氧化氢酶 （CAT） 和谷胱甘肽过氧化物酶 （GSH-PX） 活性水平升高。同时，DPC1 改善了小鼠脑组织的病理变化。此外，DPC1 对小鼠脑组织中的线粒体膜电位 （MMP） 和 ATP 含量均具有修复作用。DPC1 处理组能够通过 AMP 活化蛋白激酶/沉默信息调节因子 1 （AMPK/SIRT1） 通路，通过抑制乙酰叉头盒 O1/叉头盒 O1 （Ac-FoxO1/FoxO1） 的比例来调节氧化酶，从而恢复促氧化剂/抗氧化平衡。它还降低了 P53 和 P21 的表达。结论： 我们的结果表明，DPC1 通过激活 AMPK/SIRT1 通路抑制氧化应激诱导的衰老。

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Article ID: 4725

Analysis of the occurrence and influencing factors of deep vein thrombosis in the lower extremities after radical resection of Cervical Cancer

by ling zhang, Suhui Ma, Xiaoqian Wang, Tao Yan

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective To explore the occurrence and influencing factors of lower extremity deep vein thrombosis (LEDVT) after radical resection of cervical cancer in patients. Methods: A retrospective collection was made of 162 patients with cervical cancer in our hospital from January 2021 to April 2025. All of them underwent radical resection. The incidence of LEDVT within 15 days after the operation was statistically analyzed. The patients were grouped according to the presence or absence of LEDVT. The clinical data of the two groups were compared, and the influencing factors of LEDVT occurrence were analyzed. Based on the influencing factors, a Logistic prediction model for LEDVT was constructed, and the value of this model in predicting LEDVT was evaluated through the receiver operating characteristic (ROC) curve. Results: Among 162 patients with cervical cancer, 34 patients developed LEDVT within 15 days after the operation, with an incidence rate of 20.99% (34/162). The postoperative bed rest time in the LEDVT group was longer than that in the non-LEDVT group, the proportions of FIB and receiving air pressure wave therapy were higher in the LEDVT group, and the INR and RHDS scores were lower in the LEDVT group than in the non-LEDVT group (P < 0.05). Postoperative bed rest time, FIB, INR, RHDS score, and receiving an air pressure wave therapy device are independent risk factors for LEDVT in patients with cervical cancer after surgery (P < 0.05). A risk prediction model was constructed based on the five high-risk factors shown by Logistic. Logit(P)=11.873+ postoperative bed rest time ×0.202+FIB×0.260+INR× (-0.355) +RHDS score × (-0.351) + receiving an air pressure wave therapy device (-0.319). The ROC curve was plotted. The results showed that the AUC of this risk prediction model was 0.923 (95%CI: 0.881-0.964), and the sensitivity and specificity were 80.00% and 87.69%, respectively. Conclusion: The incidence of LEDVT after cervical cancer surgery is relatively high, which is closely related to postoperative bed rest time, FIB, INR, RHDS score, and the use of air pressure wave therapy equipment. Based on this, the Logtitic model constructed has a high predictive efficiency in predicting the risk of LEDVT after surgery.

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Article ID: 4726

Analysis of Clinical Characteristics and Risk Factors for Recurrence after Hysteroscopic Resection in Endometrial Cancer Patients

by cuili niu, Xiuyin Gui, Shuqing Tian, Zhiqiang Meng

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective To investigate changes in clinical characteristics and risk factors for recurrence after hysteroscopic resection in endometrial cancer patients. Methods  This study enrolled 108 endometrial cancer patients who underwent hysteroscopic resection at our hospital from January 2022 to June 2023. All participants received two-year postoperative follow-up through outpatient visits and telephone interviews, with subsequent stratification into recurrence and non-recurrence groups based on documented recurrence status. The postoperative recurrence was recorded, and the patients were divided into the recurrence group and the non-recurrence group based on whether they had a recurrence. General information, laboratory tumor marker indicators, pathological features and other relevant data were collected through the hospital's electronic medical record system. The related risk factors affecting the recurrence of endometrial cancer patients after hysteroscopic electroresection were further analyzed. Results   Among the 108 patients with endometrial cancer included in this study, adenocarcinoma was the most common pathological type, accounting for 69.44%, and most of them were at stage I-II (78.65%) with early-stage lesions. After a 2-year follow-up after hysteroscopic electroresection, 24 cases (22.22%) recurred and 84 cases (77.78%) did not. There were statistically significant differences in serum CA125 levels, histopathological grades, lymph node metastasis, depth of myometrial invasion, tumor diameter, para-aortic lymph node dissection, and postoperative hormone therapy between the recurrence group and the non-recurrence group ( P  <0.05). The results of multiple logistic regression analysis showed that serum CA125, histopathological grade G3, lymph node metastasis, myometrial invasion depth≥1/2, tumor diameter > 2 cm, no para-aortic lymph node dissection, and no postoperative hormone therapy were risk factors for recurrence after hysteroscopic electroresection in patients with endometrial cancer (OR>1, P <0.05). Conclusion: The recurrence rate after hysteroscopic electroresection for endometrial cancer is relatively high and is related to factors such as serum CA125 levels, histopathological grades, lymph node metastasis, depth of myometrial invasion, and tumor diameter.

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Article ID: 4640

Research Progress on the Risk Factors for the Transition from Mild Cognitive Impairment to Alzheimer's Disease

by han luo

Psycho-Oncologie , Vol.19, No.1s, 2025;

中国已进入老龄化社会，阿尔茨海默病是老年人死亡的主要原因之一。轻度认知障碍是正常认知功能和痴呆之间的关键过渡阶段。MCI 向 AD 的进展已成为一个关键的科学问题。本文总结了 MCI 向 AD 转变的危险因素的最新研究进展。它可以为疾病的早期临床筛查、评估和治疗提供靶点，并为延缓疾病进展和改善治疗结果提供基础。本研究对于深化该领域的研究，减轻社会情感负担和医疗保健负担具有重要意义。

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Article ID: 4743

Developing a predictive model for evaluating the efficacy of disulfidptosis-related biomarkers in colon adenocarcinoma

by Junshuai Lv

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background: This study investigated colon adenocarcinoma (COAD), one of the most common types of cancers worldwide. In recent years, a novel cell death pathway, hydrogen sulfide poisoning, has been identified and targeting disulfide reductase has emerged as a new strategy for cancer treatment. However, the predictive potential of disulfidptosis-related genes (DRGs) in COAD and their characteristics in the tumor immune microenvironment (TIME) remain to be further elucidated. Methods: This study obtained DRGs transcriptome and mutation data of COAD samples were obtained from the Tissue Cancer Genome Atlas (TCGA) database. Pearson and differential expression correlation analysis were used to identify COAD-related DRGs and a risk prognosis model for DRGs was constructed using the univariate least absolute shrinkage and selection operator (LASSO) and Cox regression analysis. Enrichment analysis was then conducted to explore the potential biological functions and signal transduction of differentially expressed genes associated with the model. The reliability of the model was validated through various statistical analyses such as survival analysis, receiver operating characteristic (ROC) curves, calibration plots, and bar graphs. The relationship between the prognostic model, immune microenvironment, and drug sensitivity was examined. Finally, specimens from COAD patients were extracted from the human protein atlas (HPA) database and our Hospital and compared with normal tissues to verify the expression level of DRGs. Results: We successfully established a risk prognostic model containing 6 DRGs (RPA2, TIMP1, WDR1, POLR3K, KTI12, and RTKN). This model performed well in predicting the overall survival of patients with COAD. Validation of this model through Cox analysis and clinical indicators showed considerable potential for predicting the prognosis of patients with COAD. Furthermore, there was a significant correlation between the DRGs prognostic model and tumor microenvironment (TME), immune infiltrating cells, and drug sensitivity (p < 0.05). HPA and experimental results verified that the expression levels of RPA2, TIMP1, POLR3K, KTI12, and RTKN in COAD tumors were higher than those in normal tissues, while the expression levels of WDR1 were opposite (p < 0.01). Conclusion: This study constructed a risk model and identified 6 DRGs as potential molecular therapeutic targets for COAD. The prognosis and immune therapeutic response of patients with COAD are related to DRGs, and targeted therapy for DRGs may provide a new research direction for the diagnosis and treatment of COAD.

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Article ID: 4634

Relationship between cancer-caused fatigue and negative emotions in gastric cancer patients undergoing daytime chemotherapy and the effect of positive thinking intervention

by yamin xu

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的： 探讨日间化疗胃癌患者癌症引起的疲劳与负面情绪之间的关系，并评估积极思维干预对改善癌症引起的疲劳、负面情绪和患者生活质量的影响。 方法： 选取 120 例胃癌患者，随机分为干预组和对照组，每组 60 例。对照组接受常规护理，干预组在常规护理基础上接受 8 周的积极思维干预。采用 Piper 疲劳量表评估癌症引起的疲劳，采用 SAS 和 SDS 评估负面情绪，EORTC QLQ-C30 分别评估干预前、干预后第 4 周和第 8 周的生活质量，记录干预依从性和不良反应。 结果： 癌症引起的疲劳与消极情绪呈显著正相关 （P<0.05）。干预后，干预组癌症引起的疲劳评分显著低于对照组 （P<0.05），焦虑抑郁评分显著降低 （P<0.001），生活质量评分显著升高 （P<0.001），睡眠质量显著改善 （P<0.05）。干预组对干预的依从性为 93.33%，无严重不良事件，仅部分患者报告短暂不适，不影响干预的继续。 结论： 积极思考干预可显著改善日间化疗胃癌患者癌症引起的疲劳、消极情绪、生活质量和睡眠质量，具有较高的依从性和安全性，适合在临床护理中推广应用。

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Article ID: 4633

Analysis of Risk Factors and Prognosis of Venous Thromboembolism During Pregnancy and Puerperium

by zhiqiang ruan

Psycho-Oncologie , Vol.19, No.1s, 2025;

Venous thromboembolism (VTE) during pregnancy and puerperium is one of the important health risks for perinatal women, including deep vein thrombosis (DVT) and pulmonary embolism (PE), which can endanger the lives of mothers and infants in severe cases. Hypercoagulable state during pregnancy, uterine compression, hemodynamic changes and limited postpartum activities all increase the risk of VTE, especially those who have undergone cesarean section and have a history of VTE. There are differences in the prevention strategies of VTE in national guidelines. The Royal College of Obstetricians and Gynecologists (RCOG) adopts a hierarchical management model, while the American College of Obstetricians and Gynecologists (ACOG) is relatively conservative and only recommends drug prevention for high-risk groups, while Canada adopts an intermediate strategy. Based on the characteristics of the Asian population, the domestic expert consensus proposes that localized high-risk factors such as dynamic monitoring of D-dimer, BMI ≥ 28 kg/m², preeclampsia, and assisted reproductive pregnancy be included in the risk assessment system to improve the accuracy of VTE prevention and control. In terms of preventive measures, non-drug interventions (such as early mobilization and gradient compression stockings) are the basis, and low molecular weight heparin (LMWH) is currently recognized as the first choice of anticoagulant drugs, but its timing, dosage and bleeding risk are still controversial. Studies have shown that LMWH can effectively reduce the incidence of VTE, but it may increase the risk of poor postoperative wound healing and bleeding, suggesting that the clinic needs to balance the benefits and risks of prevention, especially in optimizing medication strategies in the general maternal population.

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Article ID: 4749

Analysis of the Effect of Preventive Acupoint Massage on Perioperative Deep Vein Thrombosis (DVT) in Patients Based on the ERAS Concept

by xiaowei bai, na jing, Zihui Wang, Cuili Niu

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To analyze the effect of preventive acupoint massage on perioperative deep vein thrombosis (DVT) in patients based on the Enhanced Recovery After Surgery (ERAS) concept. Methods: The clinical data of 116 gynecological patients who received laparoscopic total hysterectomy in the hospital from February 2022 to February 2023 were analyzed retrospectively. They were divided into a control group (n=58, receiving conventional perioperative care) and a study group (n=58, receiving conventional perioperative care plus preventive acupoint massage based on the ERAS concept) according to different perioperative nursing plans. The lower limb deep vein blood flow velocity and lower limb swelling degree before surgery and 7 days after surgery were compared between the two groups. Statistics were collected on nursing satisfaction and the incidence of lower limb DVT within 3 months postoperatively. Results:  Compared with pre-operative levels, the blood flow velocity of the common femoral vein (CFV), superficial femoral vein (SFV), and popliteal vein (PV) in the affected limb increased in both groups 7 days after surgery. Furthermore, compared to the control group, the blood flow velocity of the CFV, SFV, and PV in the affected limb of the study group was significantly higher ( P <0.05). Compared with pre-operative measurements, the thigh circumference and calf circumference of the affected limb increased in both groups 7 days after surgery; however, the increases in thigh circumference and calf circumference in the study group were significantly smaller than those in the control group ( P <0.05). Compared to the control group, the study group showed higher nursing satisfaction and a significantly lower incidence of lower limb DVT within 3 months postoperatively ( P <0.05). Conclusion:  Preventive acupoint massage based on ERAS concept can improve the blood flow velocity and swelling degree of the affected lower extremity after gynecological laparoscopic surgery, reduce the risk of DVT of the lower extremity, and have high nursing satisfaction.

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Article ID: 4632

Analysis of Heart Rate Variability Among Patients in Functional Examination Department of a Hospital in Shanghai from 2023 to 2024

by jinfeng jin

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective The characteristics of heart rate variability (HRV) in patients in the functional examination department of a Shanghai hospital from 2023 to 2024 were analyzed. Methods   Ninety-five patients who received functional examination in our hospital from 2023 to 2024 were selected as the study objects, including 33 patients with depression, 32 patients with anxiety, and 30 patients with insomnia. Hrv-related indicators of patients with depression, anxiety and insomnia were compared respectively: The standard deviation (SDNN) of the difference of heartbeat cycles, the whole process is divided into consecutive periods by 5 minutes, the mean value of N-N interval every 5 minutes is calculated, then the standard deviation (SDNN5) of all the mean values are calculated, and the number of beats in all N-N interval periods where the difference between adjacent N-N interval periods is greater than 50ms is divided by the total number of NN interval periods. Finally, multiply by 100 (pNN50), the root-mean-square value (RMSSD) of the difference between all adjacent N-N intervals, extremely low frequency power (VLF), low frequency power (LF), high frequency power (HF), total power (TP), LF/HF. The HRV-related indexes of patients of different genders and ages were compared respectively: SDNN, SDNN5, pNN50, RMSSD, VLF, LF, HF, TP, LF/HF. Results  There was no significant difference in the levels of SDNN, SDNN5, pNN50, RMSSD, VLF, LF, HF, TP and LF/HF in patients with depression, anxiety and insomnia ( P  > 0.05). There was no significant difference in SDNN, SDNN5, pNN50, RMSSD, VLF, LF and TP between male and female patients ( P  > 0.05). There were significant differences in HF and LF/HF levels between male and female patients ( P  < 0.05). There were significant differences in the levels of SDNN, SDNN5, VLF, LF, TP and LF/HF among different age groups ( P  < 0.05). There was no significant difference in pNN50, RMSSD and HF levels among different age groups ( P > 0.05). Conclusion   HRV has a certain predictive power for patients with depression, anxiety and insomnia in the functional examination department of a Shanghai hospital from 2023 to 2024. In addition, the HF and LF/HF levels of HRV related indicators may be correlated with gender. At the same time, with the increase of age, the levels of SDNN, SDNN5, VLF, LF, TP, LF/HF showed a decreasing trend, and the autonomic nervous system function of the body was also declining.

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Article ID: 4763

Construction of a prediction model of adverse prognosis risk of urokinase intravenous thrombolysis in ACI patients and the prediction value of serum PPAR-γ and leptin levels

by Na Chen, dali xue, junbo wang, lijing zhao

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective   To explore the risk factors influencing the poor prognosis of urokinase intravenous thrombolysis in patients with acute cerebral infarction (ACI), analyze the predictive value of serum PPAR-γ and leptin levels, and construct an effective predictive model. Methods   One hundred patients with ACI who received urokinase intravenous thrombolysis in our hospital from November 2020 to December 2021 were selected as the research subjects, and the clinical data were collected and retrospectively analyzed. All patients were followed up for three months, and the prognosis of the patients was evaluated according to the modified Rankin scale (mRS) score, and those with mRS score ≥4 were included in the poor prognosis group (n=28). Those with an mRS score less than 4 points  were included in the good prognosis group (n=72). The risk factors influencing the poor prognosis of patients with ACI were screened using 2-test and t-test, and the high risk factors were identified through the logstic regression model, and a prediction model was constructed. The risk factors and the prediction efficiency of the prediction model on the poor prognosis of patients were analyzed through the ROC. Results   The incidence of poor prognosis in ACI patients treated with thrombolytic therapy with urokinase was 28.00%, and the proportion of patients in the poor prognosis group who were accompanied with atrial fibrillation, the time from onset to intravenous thrombolysis > 4.5h, and NIHSS score > 10 before thrombolysis was significantly higher than that in the control group (P < 0.05). The serum the levels of PPAR-γ and Leptin in the poor prognosis group were higher than those in the good prognosis group (both P < 0.05).  Logistic regression analysis showed that combined atrial fibrillation, NIHSS score > 10 before thrombolysis, time from onset to intravenous thrombolysis > 4.5h, and high serum PPAR-γ and Leptin levels were all independent risk factors for poor prognosis of urokinase intravenous thrombolysis in patients with ACI (P < 0.05). ROC curve research results showed that: The AUC for predicting adverse prognosis in patients with ACI based on the combination of atrial fibrillation, time from onset to intravenous thrombolysis (> 4.5h), NIHSS score before thrombolysis (> 10 points), high serum PPAR-γ level and Leptin level was 0.666 (95%CI: 0.540-0.792), 0.614 (95%CI: 0.482-0.746), respectively. 0.781 (95%CI: 0.676-0.887), 0.694(95%CI: 0.572-0.816), 0.712 (95%CI: 0.592-0.832); The specificity were 62.53%, 60.04%, 78.15%, 75.08% and 46.92%, respectively. The specificity was 67.51%, 61.73%, respectively. 67.59%, 60.03% and 87.55%, The ROC AUC of the predictive model for predicting adverse outcomes in patients with ACI was 0.879 (95%) CI: 0.802-0.956), with a sensitivity of 84.43%, specificity of 77.56%, and Jordan Index of 0.619.Conclusion  There are many risk factors affecting the poor prognosis of patients with ACI after  intravenous thrombolysis with urokinase, among which the NIHSS score, serum PPAR-γ level and Leptin level have better prediction efficiency before thrombolysis. The predictive model constructed in this study has high predictive value for poor prognosis of patients with ACI, which is worthy of clinical reference.

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Article ID: 4628

Nrf2 and Keap1 Gene Polymorphisms and Lower Extremity Atherosclerosis in the Elderly

by Bihua Wu, Kejing Zhou

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To investigate the association between Nuclear factor-erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) gene polymorphisms and lower extremity atherosclerotic disease (LEAD) in elderly individuals, and to develop a risk prediction model for LEAD. Methods: A total of 198 elderly inpatients diagnosed with lower extremity atherosclerosis by vascular ultrasound at the Affiliated Hospital of North Sichuan Medical College from November 2023 to November 2024 were enrolled as the case group. Sixty-six healthy individuals aged over 60 years without LEAD were randomly selected as controls. Polymorphisms at three gene loci (Nrf2 rs6721961, Nrf2 rs35652124, and Keap1 rs1048290) were analyzed using the TaqMan probe method. Various clinical indicators were included, and multiple logistic regression analyses were performed to construct prediction models. Results 1. Impact of gene polymorphisms on LEAD: Univariate analysis showed significant differences in genotype distributions of Nrf2 rs6721961 and Keap1 rs1048290 between cases and controls (P<0.05), while no significant difference was observed for Nrf2 rs35652124 (P>0.05). Logistic regression analysis indicated that carrying the TT genotype of Nrf2 rs6721961, along with a history of smoking and elevated LDL concentration, were significant risk factors for LEAD. 2. Evaluation of prediction model effectiveness: Among various constructed models, Model 3, which included the Nrf2 rs6721961 genotype, hypertension, smoking history, and LDL levels, showed better agreement between predicted and actual risk compared to models utilizing only genetic or clinical indicators. Model 3 effectively identified high-risk patients. Conclusion: 1. A significant association exists between polymorphisms at Nrf2 rs6721961 and Keap1 rs1048290 and the occurrence of lower extremity atherosclerosis in elderly individuals; however, Nrf2 rs35652124 is not significantly associated. 2. Clinical sequencing of the Nrf2 gene combined with relevant clinical indicators and predictive modeling can aid in early clinical intervention for LEAD in elderly populations.

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Article ID: 4736

Development of a Microbiome-Based Prognostic Signature for Survival Prediction and Therapeutic Stratification in Colorectal Cancer

by Shiyi Xu, Hong Ye, Xuejie Gao

Psycho-Oncologie , Vol.19, No.1s, 2025;

抽象 瘤内细菌效应最近得到了强调。在这项研究中，我们使用 TCGA 数据开发了一种基于微生物组的特征来预测结直肠癌的总生存期 （OS）。我们通过单变量 Cox 回归确定了 5 种微生物，并使用多变量 Cox 回归和生存随机森林算法改进了模型。根据中位数评分，我们将样本分为高危组和低危组，显示高危组的预后明显较差 （p < 0.01）。此外，我们发现特征与年龄、性别或 TNM 分期等临床因素之间没有显着相关性，但在多变量分析中保留了独立的预后价值 （p < 0.01）。我们还分析了基因组突变，CSMD3 在风险组之间显示出显着差异。差异表达基因 （DEGs） 富集于离子通道，尤其是钙通道和免疫相关途径中。拷贝数变异分析显示高危组扩增更多。此外，使用多种算法的免疫细胞浸润分析突出了风险组之间的显著差异，尤其是在初始 B 细胞、CD4+ T 细胞和 CD8+ T 细胞中。药物反应分析确定了几种药物，包括吉西他滨和索拉非尼，在低风险组中具有更高的敏感性。我们的研究为利用瘤内微生物群治疗结直肠癌提供了一种新的工具和见解。

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Article ID: 4784

Relationship between the timing and mode of termination of pregnancy and maternal and infant outcomes in full-term primiparous premature rupture of membranes

by xueling zhang, Jingya Li, Zhexia Hu, Biyun Luo, Lishe Chen

Psycho-Oncologie , Vol.19, No.1s, 2025;

objective: to  explore the different ways of timing and termination of pregnancy to full term premature rupture of membranes first-timer maternal and outcomes. Selection methods: from May 2019 to May 2022 treated 320 cases of full term bond position as head of premature rupture of membranes, maternal according to rupture to the length of time to termination of pregnancy, childbirth time is divided into four groups: Including < 12 h group (rupture to the delivery time less than 12 h), 12 ~ 24 h group (rupture to delivery time 12 hours or more but less than 24 hours), 24 ~ 48 group (rupture to delivery time 24 hours or more but less than 48 hours), or greater 48 h group (rupture to the delivery time is greater than or equal to 48 hours).Compare pregnancy time with different modes of delivery and outcomes. Results:  under different time to termination of pregnancy, four groups of vaginal delivery (including midwifery, shun deliser), cesarean delivery (including social factors cesarean section, cesarean section), baby total incidence of poor prognosis, maternal aderse outcome, compared to the total incidence of statistically significant difference (P < 0.05). Different delivery modes, four groups of neonatal prognosis total rate, maternal outcome, compared to the total incidence of statistically significant difference (P < 0. 05). Conclusion: th e different timing and termination of pregnancy and outcomes are different, the way of termination time < 12 h for the optimal timing of termination of pregnancy, can improve its and outcomes, reduce the incidence of adverse outcomes.

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Article ID: 4722

Efficacy observation and prognostic analysis of sling exercise therapy combined with warm acupuncture moxibustion in the treatment of patients with rotator cuff injuries: A 6-week randomized controlled trial

by Feiyu chen

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective :   To evaluate the clinical efficacy, advantage and continuity of rotator cuff elasticity and shoulder joint function of sling exercise therapy(SET) combined with warm acupuncture moxibusion in the treatment of patients with rotator cuff injuries(RCI) using shear wave elastography(SWE). 方法 ： 收集 2022 年 3 月至 2023 年 3 月在杭州中医院针灸康复科门诊就诊的患者。将 60 例肩袖损伤患者随机分为治疗组和对照组各 30 例。对照组 1 例因中午出行而移位，共计 59 例。两组均接受关节松动的基本治疗。对照组给予温针灸 （WAM） 治疗，治疗组在对照组基础上联合 SET 悬吊训练，持续 6 周。采用视觉模拟评分 （VAS） 、肩关节活动度 （SAROM） 、杨氏模量 （E） 和肩袖生活质量指数 （RC-QOL） 评价患者治疗前后的疼痛强度、肩关节活动度、肩袖肌腱弹性、生活质量，比较两组患者的临床疗效。治疗结束时再次评估 VAS 进行 3 个月的随访，观察治疗效果的稳定性。 结果 ： 与治疗前相比，治疗后两组患者的 VAS 和 E 降低，SAROM 和 RC-QOL 升高，差异有统计学意义 （ P <0.05）。治疗结束时，与对照组相比，治疗组外展 SAROM 和 RC-QOL 的 VAS 和 E 增加显著降低，两组间差异有统计学意义 （ P <0.05）。治疗组内收、内旋和外旋 SAROM 范围扩大，但与对照组相比差异无统计学意义 （ P >0.05）。治疗组临床有效率为 96.67%，对照组为 79.67%，差异有统计学意义 （ P <0.05）。治疗结束后 3 个月的随访中，治疗组的 VAS 低于治疗结束时的同组。它也低于对照组。差异有统计学意义 （ P <0.05）。相比之下，对照组的 VAS 与同组相比没有显著变化，差异无统计学意义 （ P >0.05）。 结论 ： SET 联合 WAM 可有效缓解 RCI 患者的疼痛，改善肩关节功能、肩袖弹性，提高生活质量。与单独治疗 WAM 相比，SET 干预在缓解疼痛方面效果更稳定、更持久。 关键词： 肩袖损伤;温针灸;吊带运动疗法;剪切波弹性成像;杨氏模量

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Article ID: 4809

To analyze the incidence and influencing factors of lower extremity deep vein thrombosis in patients with endometrial cancer after radical surgery

by sijin shen, Juan Li

Psycho-Oncologie , Vol.19, No.1s, 2025;

To  evaluate the incidence of lower extremity deep vein thrombosis (DVT) in patients with endometrial cancer after radical resection, and to investigate the related influencing factors. Methods: A total of 105 patients with endometrial cancer who underwent radical resection in our hospital from November 2022 to November 2023 were  selected  to observe the occurrence of postoperative DVT, and were divided into DVT group and non-DVT group. Logistic regression model was constructed to analyze the influencing factors of DVT in patients with endometrial cancer after radical resection. Results  The incidence of DVT was 17.14% (18/105) 3 days after radical resection of endometrial cancer. The age ≥60 years old, the proportion of diabetes, the proportion of operation time ≥2 hours, and the expression level of D-D in the occurrence group were higher than those in the non-occurrence group, and the differences were statistically significant (P < 0.05). There were no significant differences in long-term smoking, long-term drinking, emaciation, degree of differentiation, hypertension, tumor stage, history of varicose veins, nerve invasion, TT and FIB levels between the two groups (P > 0.05). Logistic multiple regression model showed that age, diabetes, operation time and high level of D-D were the influencing factors of lower extremity deep vein thrombosis in patients with endometrial cancer after radical operation (OR > 1, P < 0.05). Conclusions Patients with endometrial cancer have a higher risk of DVT after radical operation, and there are many influencing factors. Age, diabetes, operation time and high level of D-D are the influencing factors of DVT in patients with endometrial cancer after radical  operation.

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Article ID: 4714

Efficacy and Safety profile of combined regimen of dabrafenib and trametinib in Lung Cancer patients with BRAF mutation

by Jiadong Zhang, Zhuqi Li, Jingpeng Gao, Liyu Mao

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract Introduction:  In China, adenocarcinomas and BRAF mutations are both features of non-small cell lung cancer. In particular, targeted medicines have improved outcomes for women who have BRAF V600E mutations and who do not smoke. Due to the wide variety of BRAF mutations and fusion partners, sophisticated mutation detection approaches are required. When compared to conventional chemotherapy, immunotherapy and BRAF inhibitors are preferable. 宗旨和目标： 本研究的目的是评估达拉非尼和曲美替尼联合治疗诊断为肺癌并携带 BRAF 突变的个体的有效性和安全性。 方法： 我们医院的这项多中心回顾性研究检查了达拉非尼和曲美替尼治疗的 BRAF V600E 突变晚期 NSCLC 患者的临床特征和结果。PFS 和 OS 是主要试验目标，还有患者人口统计学和安全性。这项学术研究涵盖了连续的成人 NSCLC 患者，并非由行业资助。达拉非尼和曲美替尼在各种 NSCLC 治疗情况下的疗效和安全性得到了该研究通过不估算缺失数据来致力于数据完整性的支持。 结果： 表 1 显示了 60 名晚期癌症患者的人口统计数据，分为“第一线”（n = 9）和“第二线”（n = 51）类别。各组之间存在显着的年龄和吸烟状况差异。图 1 和图 2 使用中位无进展生存期百分比显示了治疗随时间推移的有效性。图 3 显示了不同时间间隔的累积无进展生存概率，以分析疾病进展和生存趋势。 结论： 这项真实世界试验证实了达拉非尼联合曲美替尼对 BRAF V600E 突变 NSCLC 患者（已治疗和未治疗）的疗效和安全性。回顾性设计和选择偏倚等局限性需要前瞻性调查。

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Article ID: 4713

Preventive effect and prognosis of carbetocin on postpartum hemorrhage

by Yan Cui, Jialei Zhu

Psycho-Oncologie , Vol.19, No.1s, 2025;

【摘要】 目的 ： 探讨卡贝缩宫素在医院产后出血（PPH）治疗中的临床价值。 方法 ： 从 2018 年到 2022 年，共纳入 38948 例住院的高危产妇。所有产妇均接受卡贝缩宫素治疗，并比较和分析治疗效果。 结果： 所有产妇均出现产后出血，新生儿状况良好。与产前相比，产后经阴道分娩后产后血红蛋白 （Hb） 、红细胞体积 （RCV） 和红细胞计数 （RBC） 均降低，遗憾无统计学意义 （P > 0.05）。此外，不良反应的总发生率为 0.1% （11/38948），较低。此外，我们发现 2019 年后卡贝缩宫素的年剂量逐年减少，这可能与中国新生儿出生率的下降有关。 结论： 卡贝缩宫素的使用在一定程度上缓解了阴道分娩妇女 PPH 的临床适应症。然而，产前和产后生物标志物之间没有显著差异。

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Article ID: 4825

The diagnostic value of circulating miRNA-125b and miRNA-144 in gestational diabetes mellitus

by yanying wu, Lijie Shen, Xin Zhang, Fengzhen Guo

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract - Background: Gestational diabetes mellitus (GDM) poses a major threat to maternal and fetal health, and it is essential to find reliable biomarkers for early diagnosis. Circulating micrornas (mirnas) have shown great diagnostic potential in metabolic diseases. This study aims to evaluate the expression pattern and diagnostic value of peripheral blood miRNA-125b and miRNA-144 in GDM patients. Methods: A case-control study was conducted. Peripheral blood samples were collected from 120 pregnant women (60 GDM patients and 60 healthy controls) at 24-28 weeks of gestation. The expression levels of miRNA were quantified by qRT-PCR, and the diagnostic efficacy was analyzed by receiver operating characteristic (ROC) curve. Results: The expression of miRNA-125b in the GDM group was significantly down-regulated (0.45±0.12 vs. 1.00±0.18, p<0.001), while the expression of miRNA-144 was significantly up-regulated (2.83±0.67 vs. 1.00±0.21, p<0.001). The AUC of miRNA-125b in the diagnosis of GDM was 0.87(95%CI: 0.81-0.93), the sensitivity was 82.5%, and the specificity was 85.0%. The AUC of miRNA-144 was 0.91(95%CI: 0.86-0.96), the sensitivity was 88.3%, and the specificity was 83.3%. The combination of mirNA-125b and GDM significantly improved the diagnostic efficiency (AUC: 0.95, sensitivity 93.3%, specificity 90.0%). Conclusions: Circulating miRNA-125b and miRNA-144 are significantly differentially expressed in GDM patients and can be used as efficient non-invasive biomarkers for the diagnosis of GDM. The combination of mirNA-125b and mirNA-144 has significant clinical value.

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Article ID: 4703

A Comparative Transcriptomic Analysis of Pathogenic Mechanisms between Papillary Thyroid Carcinoma and Hashimoto's Thyroiditis

by Xuelu Xu, Yuqing Ma, Jie Yang, Weibin Fan, Wenxia Wang, Zhizheng Xu

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract 甲状腺状癌 （PTC） 和桥本氏甲状腺炎 （HT） 看起来是拮抗性的，但经常同时发生。本研究整合了四个 GEO 数据集，以比较 PTC 、 HT 、 PTC_HT 和对照甲状腺组织 （对照） 之间的基因表达差异，揭示基因表达的相似性和差异性。结果显示 3 种情况下 202 个基因存在显著差异，上调/下调趋势一致，主要涉及炎症和趋化因子 （例如 CXCL8、CXCL9、CXCL10、IL8）。PTC 和 HT 中的细胞处于慢性炎症激活状态，对 p53 和 FAS 诱导的凋亡信号无反应。PTC 和 HT 之间差异表达基因的分析表明，几个细胞外基质通路基因 （例如 FN1、LAMB1、LAMC1） 在两种疾病中具有相反的表达趋势，FN1-DUSP6-ETV5-NFATC1/3 信号轴可能通过调节 T 细胞免疫反应来驱动表型异质性。这些发现为 PTC 和 HT 的分子机制和相互关系提供了新的见解。

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Article ID: 4852

The application of multi-part collaboration in improving the on-time opening rate of the first interventional surgery

by hui chen, Zhifeng Gu

Psycho-Oncologie , Vol.19, No.1s, 2025;

  Objective To explore methods for improving the on-time opening rate of the first interventional procedure and further enhance the efficiency of the catheterization laboratory. Methods : A retrospective analysis was conducted on the on-time opening rate of the first surgeries in our hospital from April to September 2024, and the reasons for the delay in the opening time of the first surgeries were analyzed. Systematic intervention was carried out with the aid of scientific management tools. The results showed that the rate of on-time opening of the first operation was increased to 88.08% after systematic intervention. Conclusion Through the collaboration and close coordination of multiple departments and departments, the efficiency of the catheterization laboratory was effectively improved, and the satisfaction of patients and medical staff was also enhanced.

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Article ID: 4701

The Clinical Value of Leukocyte-Reduced Blood Component Transfusion in the Treatment of Elderly Cancer Patients

by Weina Wang, Zhiyong Xing

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract Objective : This study aims to evaluate the clinical value of leukocyte-reduced blood component transfusion in elderly cancer patients undergoing transfusion therapy. 方法 ： 共纳入 2022 年 8 月至 2023年8月在我院接受输血治疗的 80 例老年癌症患者。根据输血方法，将患者分为对照组 （n=40，常规悬浮红细胞输注） 和实验组 （n=40，白细胞减少成分输注）。比较两组治疗效果、不良反应发生率、术后感染率和手术切口愈合时间。 结果 ： 与对照组相比，实验组临床疗效明显升高，不良反应和术后感染发生率更低，切口愈合时间更短。差异具有统计学意义 （P < 0.05）。 结论 ： 白细胞减少成分输注满足老年癌症患者的临床需求，显著提高治疗效果，减少不良反应和感染，缩短切口愈合时间。因此，建议在临床上更广泛地采用。

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Article ID: 4894

Divergent Phenotypes and Persistent Disability: A Comparative Cohort Study of Arterial Ischaemic and Haemorrhagic Stroke in Chinese Paediatric Patients

by dongyanqing, chunmei yao, yaxian deng, Jingyuan song, Manman Niu, Xingmeng Li, yajie Wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background:  Paediatric stroke poses a significant clinical challenge with lifelong disability risks. However, comparative analyses delineating subtype-specific manifestations and outcomes between arterial ischemic stroke (AIS) and haemorrhagic stroke (HS) are lacking. Objective:  To characterize and compare the AIS and HS subtypes in a paediatric cohort, focusing on clinical presentation, aetiology, lesion distribution, and outcomes. Methods: This retrospective cohort study included consecutive paediatric patients (1 month-18 years) with first-ever AIS or HS admitted to Beijing Tiantan Hospital between June 2019 and May 2024. Cases were identified through structured electronic medical record review using standardized diagnostic criteria. Results:  The cohort comprised 72 paediatric stroke cases (42 AIS, 30 HS) with comparable age distributions (median 8.0 vs 8.5 years) but distinct clinical profiles. While AIS patients predominantly presented with focal deficits (73.8% hemiparesis vs 30.0% in HS), HS cases more frequently exhibited diffuse symptoms, including headache (56.7% vs 11.9%) and nausea/vomiting (36.7% vs 4.8%). Etiological evaluation revealed striking differences: arteriopathies (particularly moyamoya disease and vasculitis) were dominant in AIS, whereas structural vascular anomalies (arteriovenous malformations [AVMs] and cavernomas) were characteristic of HS. At the 12-month follow-up, persistent neurological sequelae were common in   both groups (AIS 67.6%, HS 64.3%), though disability patterns diverged; AIS survivors demonstrated predominantly motor deficits (56.8% vs 28.6%) while cognitive impairment was more prevalent in HS (21.4% vs 13.5%). Mortality rates remained low (AIS 2.7%, HS 7.1%), with recurrence observed exclusively in AIS cases (5.4%). Conclusion : Acute paediatric AIS and HS exhibit distinct clinical phenotypes—focal neurological deficits are predominant in AIS versus diffuse symptoms (headache/nausea) in HS, enabling early syndromic differentiation. Despite treatment, persistent neurological morbidity affects >64% of survivors, with subtype-specific disability patterns: AIS is primarily associated with motor impairments, while HS demonstrates greater cognitive sequelae. The low mortality (<7.1%) and recurrence rates reflect advancements in care, yet the enduring disability burden underscores the necessity for subtype-tailored rehabilitation and systematic long-term surveillance.

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Article ID: 4689

Integrated Traditional Chinese and Western Medicine for Non-Surgical Management of Stanford Type B Aortic Dissection: A Case Report and Clinical Observation

by Yuncheng Xiao

Psycho-Oncologie , Vol.19, No.1s, 2025;

摘要：目标： 主动脉夹层是一种危及生命的心血管急症。虽然手术干预是 Stanford A 型夹层的标准治疗方法，但对于稳定的 Stanford B 型病例，尤其是老年患者或有合并症的患者，通常首选保守治疗。将中医 （TCM） 与西医方法相结合可能会为非手术病例提供额外的好处。 方法： 本病例报告介绍了一名 70 岁男性患者，诊断为斯坦福 B 型主动脉夹层，他使用综合治疗策略进行了非手术治疗。西医方案包括血压控制、疼痛缓解、抗凝和感染管理。同时，患者接受了针对“气滞、血瘀、心阳虚”证的中医干预，包括中药煎剂（以血府竹玉汤）、针灸、艾灸等。通过症状缓解、生命体征稳定和影像学检查结果评估治疗效果。 结果： 综合治疗 15 天后，患者的胸痛和乏力明显缓解。血压保持在目标范围 （110–120/70–80 mmHg） 内，心率稳定在 60 次/分钟以下。影像学检查（CT 血管造影）证实夹层没有进一步扩大或进展。患者出院时情况稳定，并报告生活质量和功能状态有所改善。 结论： 本病例表明，中医结合西医可能是治疗非手术患者 Stanford B 型主动脉夹层的一种安全有效的方法。联合策略可以增强症状控制，稳定血流动力学，并支持整体恢复。需要进一步的研究来在更大的队列中验证这些发现。

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Article ID: 4895

Analysis of clinical status and risk factors of blood infection of Klebsiella pneumoniae in hospital

by bing li, Lingjun Kong, Yan Sun

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective  To analyze the clinical status and risk factors of patients with blood infection caused by Klebsiella pneumoniae. Methods  110 patients with blood infection in clinical departments of our hospital from May 2022 to May 2023 were reviewed, and 130 strains of Enterobacteriaceae bacteria were isolated from blood flow samples,110 of which were Klebsiella pneumoniae (cKP).Staphylococcus aureus ATCC29213, Streptococcus pneumoniae ATCC49619, Escherichia coli ATCC25922,Enterococcus faecalis ATCC29212 and Pseudomonas aeruginosa ATCC27853 were used as quality control strains to analyze the distribution, clinical characteristics, risk factors and drug resistance of Klebsiella pneumoniae. Results  Among 130 strains of Enterobacteriaceae,110 strains of Klebsiella pneumoniae (cKP)were mainly distributed in hematology, surgery and other departments. Compared with other departments, the number of Klebsiella pneumoniae in department of hematology and surgery was significantly increased, and the difference was statistically significant ( P <0.05).There was no significant difference in the distribution of Klebsiella pneumoniae among other departments ( P >0.05). A total of 110 cases of Klebsiella pneumoniae infection were included in this study, of which 60.91% were male, 59.09% were over 60 years old, 33.64% had blood infection as the primary focus, and the infection method was mainly hospital-acquired, accounting for 69.09%. The results of single factor analysis showed that the risk factors of Klebsiella pneumoniae infection were primary lesion, treatment, acquisition, underlying disease,urinary tract intubation and blood type. Multivariate Logistic regression analysis showed that nosocomial infection,liver disease,diabetes,urinary tract intubation and blood type were independent risk factors for bloodstream infection of Klebsiella pneumoniae.The resistance rate of Klebsiella pneumoniae to piperacillin was the highest (39.92%). The resistance rate of the first to fourth generation of cephalosporins was 6.21% to 41.25%, of which the lowest resistance rate of cefotetan was 6.21%, and the highest resistance rate of cephalosporin was 41.25%. 42 ESBLs strains were detected among 110 Klebsiella pneumoniae strains, and the positive rate was 38.18%. Conclusion  Physicians should pay special attention to the infection of Klebsiella hyperpneumoniae caused by diabetes,blood type,urinary tract intubation, and pay attention to the diagnosis, treatment and infection control.

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Article ID: 4680

Meta-Analysis on the Efficacy and Safety of Platelet-Derived Growth Factor in Diabetic Foot Wound Healing

by Yunfan Zhang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract Background: Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, posing significant challenges to wound healing and increasing the risk of lower limb amputations. Platelet-derived growth factor (PDGF) has shown potential as a therapeutic agent for DFUs due to its role in promoting cellular proliferation, angiogenesis, and tissue repair. However, the efficacy and safety of PDGF remain controversial, with mixed results from randomized controlled trials (RCTs). Objective:  This meta-analysis aims to evaluate the efficacy and safety of recombinant human platelet-derived growth factor (rhPDGF) in the treatment of DFUs, focusing on clinical outcomes such as healing rates, recurrence rates, healing time, and adverse event (AE) rates. Methods: A systematic literature review was conducted across six databases (PubMed, Embase, Cochrane Library, Web of Science, CNKI, and WeiPu) to identify RCTs evaluating rhPDGF in DFU treatment. Inclusion criteria adhered to the PICOS framework. Data extraction and quality assessment were performed independently by two researchers. Meta-analysis was conducted using R software, with heterogeneity assessed via the I² statistic. Subgroup, sensitivity, and publication bias analyses were also performed. Results:  A total of 12 RCTs, involving 26,469 participants, were included. The meta-analysis demonstrated that rhPDGF significantly improved healing rates compared to control interventions (OR = 1.76, 95% CI: 1.37–2.27, P < 0.01). Subgroup analysis revealed that the 100 μg/g rhPDGF concentration was more   effective than 30 μg/g. No significant differences were found in recurrence rates (OR = 0.65, 95% CI: 0.36–1.17, P = 0.15), healing time (SMD = -0.46, 95% CI: -1.16–0.23, P = 0.19), or adverse event rates (OR = 0.84, 95% CI: 0.61–1.17, P = 0.30). Sensitivity analysis confirmed the stability of the results, and no publication bias was detected. Conclusions:  This meta-analysis provides robust evidence that rhPDGF, particularly at a concentration of 100 μg/g.

Featured Article

Article ID: 4896

The expression of MAP4K4 and HIF2α in peripheral blood of patients with locally advanced cervical cancer is correlated with excessive activation of autophagy and sensitivity to platinum-based neoadjuvant chemotherapy

by lijuan, Shen Sijin, Xiu Chen

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective : To investigate the expression of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) and Hypoxia-inducible factor 2α(hypoxia-inducible factor 2α) in peripheral blood of patients with locally advanced cervical cancer The relationship between the expression of HIF 2α and the over-activation of autophagy and sensitivity to platinum-based neoadjuvant chemotherapy in cervical cancer patients. Methods:  A total of 230 patients with locally advanced cervical cancer admitted to our hospital from August 2022 to August 2025 were prospectively selected as the research objects. The expressions of MAP4K4, HIF2α and autophagy-related genes [LC-3Ⅱ, LC-3I and Beclin-1] in peripheral blood before and after chemotherapy were detected by qRT-PCR. Pearson test was used for correlation analysis. Logistic regression model was used to analyze the independent risk factors of chemotherapy sensitivity. Results: MAP4K4  and HIF2α were expressed in peripheral blood of patients with locally advanced cervical cancer in the subgroups of age, tumor size and histological type (P > 0.05), while MAP4K4 and HIF2α were expressed in the subgroups of differentiation, FIGO stage  and lymph node metastasis (P <0.05). Before chemotherapy, MAP 4K4 mRNA and HIF2α mRN A in peripheral blood were compared between the two groups (P > 0.05). After chemotherapy, two groups of MAP4K4 mRNA, HIF2 alpha mRNA were significantly lower (P < 0.05), and effective group MAP4K4 mRNA, HIF2 alpha mRNA significantly below invalid group (P < 0.05); Before chemotherapy, LC-3Ⅱ, LC-3I and Beclin-1 were compared between the two groups (P > 0.05); After chemotherapy, LC-3Ⅱ, LC-3I and Beclin-1 in the two groups were increased, and LC-3Ⅱ, LC-3I and Beclin-1 in the ineffective group were significantly higher than those in the effective group (P <0.05). MAP4K4 and HIF2α were positively correlated with LC-3Ⅱ, LC-3I and Beclin-1 (P <0.05). The degree of differentiation, FIGO stage, lymph node metastasis, LC-3Ⅱ, LC-3I, Beclin-1, MAP4K4 and HIF2α were independent risk factors for chemotherapy sensitivity in patients with locally advanced cervical cancer (P <0.05). Conclusions: MAP4K4 and HIF2α are up-regulated in patients with locally advanced cervical cancer, which are closely related to the excessive activation of autophagy during chemotherapy and the sensitivity to platinum-based neoadjuvant chemotherapy.

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Article ID: 4798

The impact of dual antiplatelet therapy on bleeding and thrombotic risks in diabetic patients following coronary stent implantation: a prospective study

by Rui Fan, Yulong Ma

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background: Diabetes mellitus is a significant comorbidity in patients undergoing percutaneous coronary intervention (PCI) with stent implantation, and it is associated with increased risks of bleeding and thrombosis. The optimal duration and intensity of dual antiplatelet therapy (DAPT) in diabetic patients remain a subject of debate due to the delicate balance between thrombotic and bleeding risks. Objective: This prospective study aims to evaluate the impact of DAPT on the risks of bleeding and thrombosis in diabetic patients following coronary stent implantation, and to determine the optimal duration of DAPT in this high-risk cohort. Methods:  In this single-center prospective cohort study, 500 diabetic patients receiving drug-eluting stents (DES) were prescribed DAPT (aspirin + P2Y12 inhibitor). Participants were stratified into short-term (<6 months) and extended (≥6 months) DAPT groups based on actual treatment duration. Primary outcomes included major adverse cardiovascular events (MACE: cardiac death, myocardial infarction, target vessel revascularization) and BARC type 2/3/5 bleeding events. Outcomes were adjudicated by an independent blinded committee. 结果： 在 12 个月内，与短期治疗相比，延长 DAPT 显著降低了 MACE 发生率 （7.8% vs. 10.5%，HR=0.72,95% CI：0.53-0.98，P = 0.03）。 这一获益是由较低的靶血管血运重建率驱动的 （3.1% vs. 5.1%， P =0.03）。虽然总体出血率没有显著差异 （8.1% vs. 6.2%， P =0.19），但亚组分析显示，既往出血史患者的复发性出血显著增加 （HR=2.10，P=0.01 ）。 结论： 延长 DAPT 可减少糖尿病患者支架植入术后的缺血事件，而不会显着增加总体出血风险。然而，由于出血复发率增加，在有既往出血史的患者中使用需要谨慎。这些发现强调了平衡血栓形成保护和出血易感性的个体化 DAPT 策略的必要性。

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Article ID: 4587

Exploration of Physiological Reference Intervals for Thyroid Function During the First Trimester of Twin Pregnancy

by Xiangyu Liao, Xing Liang, Chongming Li, Qi Shi, Kerong Zhang

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective:To explore specific reference intervals for serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) during the first trimester of twin pregnancies in Nanchong City and compare them with those of singleton pregnancies. Methods : A retrospective analysis was conducted on 788 twin pregnancies who underwent prenatal examination and delivery at the Affiliated Hospital of North Sichuan Medical College from January 2017 to May 2024. Based on the criteria established by the National Academy of Clinical Biochemistry (NACB), 184 cases were included in the twin pregnancy group. Additionally, 537 singleton pregnancies from the same hospital and time period were randomly selected as the singleton group, and 42 twin pregnancies admitted between June and December 2024 were assigned as the non-concurrent validation group. Reference intervals for early pregnancy thyroid hormones were established using the percentile method, with the 2.5th (P2.5) and 97.5th percentiles (P97.5) of TSH and FT4 in the twin pregnancy group set as the lower and upper limits of normal thyroid function. Mann–Whitney U tests were used to compare differences between groups. The non-concurrent group was used to validate the preliminary reference intervals. The diagnostic discrepancies in thyroid dysfunction under different criteria were also analyzed. 结果： 妊娠早期双胎妊娠的 TSH 参考区间如下： 总 （T1） 0.005–4.28 mIU/L （中位数 1.15）;孕周 1-6+6 （T1-1） 0.7-4.58 mIU/L（中位数 1.87）;第 7-13+6 周 （T1-2） 0.004-4.11 mIU/L（中位数 0.78）。FT4 参考区间为：T1 0.98–2.60 ng/dl（中位数 1.29）;T1-1 1.0–1.86 ng/dl（中位数 1.24）;T1-2 0.97–2.68 ng/dl（中位数 1.32）。与单胎妊娠相比，双胎妊娠在妊娠早期表现出显着较低的 TSH 水平 （1.15 vs. 1.56 mIU/L，Z = –3.909，P < 0.01） 和较高的 FT4 水平 （1.29 vs. 1.27 ng/dl，Z = –2.882，P = 0.003）。这些差异在 T1-2 期间更为明显 （TSH： 0.78 vs. 1.25 mIU/L， Z = –3.723， P < 0.001;FT4：1.32 vs. 1.25 ng/dl，Z = –4.219，P < 0.01）。使用基于单例的参考区间或 2017 年美国甲状腺协会 （ATA） 指南导致双胎妊娠中亚临床甲状腺功能亢进症的严重过度诊断 （χ² = 34.833a，χ² = 31.233a，P < 0.01）。然而，与 ATA 2017 标准相比，应用双胞胎特异性参考区间降低了低 FT4 综合征的诊断 （χ² = 6.715a，P = 0.01）。 结论： 与单胎妊娠相比，南充市双胎妊娠早期甲状腺功能指标表现出明显的动态特征。建立双胞胎特异性参考区间至关重要。在双胎妊娠中，应用基于单胎或国际指南阈值可能会导致误诊和不适当的治疗，从而对母体和胎儿健康构成风险。因此，临床评估应优先采用为双胎妊娠量身定制的人群特异性参考标准。

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Article ID: 4761

Research progress on the application of Kirkpatrick model in continuing nursing education

by Lijuan Peng, Huan Liu, Wenfeng Xue

Psycho-Oncologie , Vol.19, No.1s, 2025;

本文综述了 Kirkpatrick 模型在继续护理教育领域的简要介绍、内容和应用现状、问题和建议，以期为后续研究和临床应用提供理论依据和实践参考。

Featured Article

Article ID: 4665

Efficacy and safety of different doses of ciprofol for general anesthesia induction in elderly patients undergoing hip replacement surgery: a randomized, double-blind, controlled clinical trial

by Xiao Tian, Haojun Sun, Yugang Diao, Bin Zou, Zitong Xu, Chunlin Yao, Lin Li

Psycho-Oncologie , Vol.19, No.1s, 2025;

抽象 背景： 环丙虫酚可用于接受大型非心脏手术的老年患者的全身麻醉诱导。本试验旨在比较三种更精确剂量的环丙福的疗效和安全性，并探索接受髋关节置换手术的老年患者诱导的最佳剂量。 方法： 该试验是一项前瞻性、随机、对照试验。将 120 例计划接受髋关节置换手术的老年患者随机分为 4 组进行全身麻醉诱导：PROP 组 （丙泊酚 1.5 mg/kg）、CIP1 （环丙酚 0.25 mg/kg）、CIP2 （环丙酚 0.30 mg/kg） 和 CIP3 组 （环丙酚 0.35 mg/kg）。主要结局是全身麻醉的诱导成功率。次要结局包括诱导成功时间、睫毛反射消失时间、所需的额外麻醉剂数量和成功诱导的总剂量。安全性指标包括低血压、高血压、心动过速、心动过缓、低氧血症、注射痛和身体运动等不良事件的发生率。 结果： 4 组全身麻醉诱导成功率为 100%。CIP3 组与 PROP 组的诱导成功时间和睫毛反射消失时间差异无统计学意义。然而，CIP1 组和 CIP2 组的这两个时间都显著增加，结果显示差异有统计学意义。CIP1 和 CIP2 组需要补充剂量和补充剂量的患者人数显著大于 PROP 和 CIP3 组。PROP 组成功诱导的总剂量是环丙酚组的 4-5 倍。环丙酚组低血压发生率显著低于异丙酚组。4 组高血压、心动过速和心动过缓的发生率差异无统计学意义。PROP 组注射痛发生率为 50%，而 3 组 CIP 组无注射痛报告。所有受试者均未出现身体运动和呼吸抑制。 结论： 环丙酚 （0.25-0.35mg/kg） 可安全有效地用于老年髋关节置换手术患者的全身麻醉诱导。0.35mg/kg 环丙酚的麻醉效果不劣于 1.5mg/kg 异丙酚，具有较高的安全性和舒适性。

Featured Article

Article ID: 4760

Are reproductive factors indicators of pregnancy-induced hypertension: a cross-sectional analysis

by Qiaoli Tong

Psycho-Oncologie , Vol.19, No.1s, 2025;

Background:  Reproductive factors are important contributors to cardiovascular diseases, but there is limited evidence regarding their relationship with pregnancy-induced hypertension (PIH). Method:  Pregnant patients who underwent physical examinations were enrolled. PIH was determined through medical records and reproductive factors, including age at menarche, menstrual irregularities, menstrual cycle, number of miscarriages or abortions, maternal age at first pregnancy, and history of oral contraceptive use, were collected through telephone follow-up. Statistical analysis included logistic regression and Spearman correlation analysis. Results: Early menarche age may increase the risk of incidence PIH (Adjusted OR=0.071, (95% CI: 0.029-0.173), P < 0.001) and a higher prevalence of cesarean section deliveries (spearman r index =-0.177, P < 0.001) and shorter gestational weeks (spearman r index =0.222, P < 0.001). However, experiencing miscarriages or abortions, using oral contraceptives, and menstrual indices, after adjusting for cofounders, were not related to PIH. Conclusion: The age at menarche is associated with pregnancy-induced hypertension (PIH) independently of genetics, age, and lifestyle factors, which emphasizes the potential importance of a woman's menstrual history in evaluating the risk of PIH.

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Article ID: 4757

Meta Analysis of the Effectiveness of Acupuncture and Moxibustion on the Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Surgery

by Shuxin Zhou

Psycho-Oncologie , Vol.19, No.1s, 2025;

Objective: To collect the relevant literature on clinical comparative experiment and clinical randomized comparative experiment of acupuncture and moxibustion to restore gastrointestinal function after gastric cancer surgery in PubMed, Cochrane Library and Embase databases. Combined with systematic review and meta-analysis, this paper explores the effect of acupuncture and moxibustion on the recovery of gastrointestinal function after gastric cancer surgery, and provides a basis for its clinical treatment.  Methods: Through computer retrieval of PubMed, Cochrane Library, and Embase databases, relevant literature is obtained in accordance with inclusive and exclusive criteria and retrieval strategies. The literature search period is set from January 1, 2012 to December 31, 2022. Performing meta-analysis using RevMan 5.3 software and evaluating the bias of the literature using the bias assessment module in Cochrane Handbook 5.1.0.  Results: According to the search strategy, a preliminary search was conducted and 523 articles were retrieved. After screening, 17 articles were ultimately included in the meta-analysis. Among the 17 included literature, 8 articles on the Rome II index were from 2000, and 5 articles were from 2002. There were 2 articles using the Rome III index from 2006, and 2 articles using gastroenterology. There were 12 and 5 articles, 6 articles, 8 articles, 5 articles, 5 articles, and 7 articles each with low risk of bias for random sequence generation, allocation concealment, implementation bias, measurement bias, follow-up bias, reporting bias, and other biases. The analysis of clinical efficacy showed that the total efficacy analysis was P =0.0001 and I 2  was 73%, indicating heterogeneity among the 8 articles with clinical efficacy as the outcome measure. After excluding sources of heterogeneity, the combined effect energy was 1.74, 95%CI =[1.65,1.89], and Z=5.76. The results of postoperative bowel sound recovery time showed that I 2 =92%, SMD value =-1.52, and 95%CI values =[-2.03, -1.02]. Postoperative first anal exhaust time: I 2 =96%, SMD=-11.57, 95%CI=[-14.76, -7.83]. First postoperative bowel movement time: I 2 =84%, SMD=-11.57, 95%CI=[-14.76, -7.83]. The heterogeneity among the three results mentioned above was significant ( P <0.0001), and the discrepancies were obvious.  Conclusion: Acupuncture and moxibustion combined with conventional treatment can promote the gastrointestinal functional recovery after gastric cancer surgery. However, due to the fact that most of the literature included in this study is at level B, there is a lack of high-quality literature support, so caution should be taken when approaching this conclusion.

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Article ID: 4672

Research on the behavioral impact path of family cluster management for school-aged children with asthma based on the COM-B model

by Feiyang Qian, Guolian Shen, Xiaoqing Bao, Yuxin Chen, Wadi Zhao, Chunming Jiang

Psycho-Oncologie , Vol.19, No.1s, 2025;

摘要： 将 COM-B 模型与家庭群体管理相结合，基于 COM-B 模型构建了学龄哮喘患儿家庭群体管理方案，探讨了该项目对学龄哮喘患儿自我管理、哮喘控制和生活质量的影响，为未来的临床护理干预模式提供了实证依据。选取 2023 年 3 月至 2023 年 8 月在杭州某三级甲等医院儿科哮喘门诊就诊的 96 例患儿作为研究对象，采用计算机随机数生成器生成随机序列，将研究对象分为对照组和实验组各 48 例。哮喘患儿对照组参与常规护理，实验组在常规护理的基础上应用基于家庭集群管理的 COM-B 模型的干预方案。COM-B 模型化的学龄哮喘患儿家庭群体管理干预方案，可以提高患儿的自我管理能力，从而有效控制哮喘，提高哮喘患儿的生活质量，为临床上更科学、更有效地管理哮喘患儿提供参考

Featured Article

Article ID: 4747

Obstructive Sleep Apnea Hypopnea Syndrome: A Comparative Study of Cardiopulmonary Exercise Testing Outcomes

by dong wang

Psycho-Oncologie , Vol.19, No.1s, 2025;

阻塞性睡眠呼吸暂停低通气综合征 （OSAHS） 是一种以睡眠期间反复出现呼吸停止或通气不足为特征的疾病，导致气流受限持续 10 秒或更长时间 [ 1]。 临床表现为打鼾、间歇性呼吸停止、夜间频繁觉醒、夜间排尿增加、睡眠质量差、白天嗜睡和认知能力下降。诊断依赖于多导睡眠图 （PSG），它监测脑电波、眼球运动和下巴肌肉张力以评估睡眠-觉醒状态，以及胸腹运动、口鼻气流和血氧饱和度，以识别呼吸暂停和低通气。心肺运动试验 （CPET） 是一种客观、无创的评估心肺储备和运动耐量的方法，不同于传统的基于心电图的运动试验和静态肺功能试验 [ 2]。 本研究旨在通过比较 OSAHS 患者与健康成人的 CPET 结果，探讨 OSAHS 患者的心肺功能变化以及 CPET 的临床应用价值。

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Article ID: 4675

Research on Multi modal Parkinson's Disease Diagnosis System Based on Deep Learning Model

by Jiaying Xu, Chao Qiu

Psycho-Oncologie , Vol.19, No.1s, 2025;

抽象 帕金森病 （PD） 是一种由多巴胺分泌减少引起的进行性神经退行性疾病。深度学习 （DL） 在 PD 诊断研究中受到广泛关注，该学科发表的论文数量也在增加。与常见的机器学习方法相比，使用 DL 的 PD 检测呈现出更有希望的结果。本文将综述机器学习和基于多模态成像的深度学习在帕金森病早期诊断、分类研究和功能预测中的应用，并解释其局限性，并对未来的发展趋势进行展望。为了实现我们的研究目标，我们从 Scopus、Web of Science、Spring、CNKI 和万方等数据库中检索并分析了可用的研究论文。

Featured Article

Article ID: 4745

A study on the correlation between serum levels of IL-33 and its receptor sST2 and GDM in pregnant women

by Yu Sun, Wei Fan, Cuihua Shen, Wei Kang, Xin Li, XiCan Liu

Psycho-Oncologie , Vol.19, No.1s, 2025;

[ Abstract ] 目的 探讨孕妇血清白细胞介素-33 （IL-33） 及其受体可溶性抑癌基因 2 （sST2） 水平与妊娠糖尿病 （GDM） 水平的相关性。 方法 回顾性分析2022年9月至 2022年9月在昆明市妇幼保健院产科接受产科定期检查的 115 例孕妇作为研究对象，根据妊娠 24-28 周的 OGTT 结果分为 GDM 组（n=53）和正常糖耐量（NGT）组（n=62）。比较两组一般资料和实验室指标的差异。通过多因素 logistic 回归分析孕妇 GDM 的风险;通过 Pearson 线性分析分析 OGT T 时 IL-33 和 sST2 水平与空腹血糖 （FPG） 和胰岛素抵抗指数 （HOMA-IR） 的相关性;采用受试者工作特征 （ROC） 曲线分析 IL-33 和 sST2 水平对孕妇 GDM 风险的预测价值。还使用 ROC 曲线分析 IL-33 和 sST2 水平对孕妇 GDM 风险的预测价值。 结果 单因素分析结果显示，GDM组空腹胰岛素（FINS）、血红蛋白（Hb）、总胆固醇（TC）、FBG、嗜酸性粒细胞计数（EOS）、谷氨酰转移酶（GGT）、HOMA-IR、IL-33、sST2高于NGT组，产后出血量和LDL低于NGT组（P<0.05）。P<0.05）;Pearson 线性相关分析显示，GDM 组血清 IL-33 水平与母体 FPG 和 HOMA-IR 呈负相关 （P<0.05），sST2 水平与母体 FPG 和 HOMA-IR 呈正相关 （P<0.05）;多因素logistic回归分析结果显示，FINS、Hb、FBG、HOMA-IR、IL-33和sST2共6项指标是孕妇发生GDM的独立危险因素（P<0.05），其中血清FINS、Hb、FBG、HOMA-IR、IL-33和sST2水平越高，GDM发生的风险越高;ROC 曲线分析结果显示：两者联合预测孕妇 GDM 发生的曲线下面积 （AUC） 为 0.911，灵敏度为 85.06%，特异度为 83.39%，与单一指标相比具有更高的预测价值 （P<0.05）。 结论 血清 孕妇发生 GDM 后 IL-33 及其 sST2 水平显著升高，血清 IL-33 及其受体 sST2 水平可用于预测孕妇 GDM 的发生，具有理想的评价价值，值得推广应用。

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Article ID: 4688

Best Evidence Summary for the Management of Pediatric Burn Wounds

by Yuanling Cong, Wenxiang Cui, Jingzhou Wang, Xiaoguang Yang

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的 ：筛选和总结管理 p 的最佳证据 ediatric burn wounds，为儿科烧伤患者的临床伤口 CAR E 实践提供循证指导。 方法 ： 遵循循证资源的 “6S” 金字塔模式，在 do mestic 和国际指南、专业协会网站和数据库中进行系统检索，以确定临床决策、指南、证据总结、最佳实践、事前共识和系统评价与 p ediatric burn 患者的评估和护理相关。检索期从 dat abase 成立到 2024 年 3 月 24 日。两名循证研究人员独立评估文献质量，从纳入的研究中提取、分类和整合证据，最终形成最佳证据。 结果 ： 共纳入 16 篇文章，包括 10 篇指南和 6 篇专家 cons ensus 文件。总结了四个关键主题：护理评估、护理、液体复苏和感染预防。共提取了 37 个最佳证据点。 结论 ： 总结的儿童烧伤创面管理的最佳证据既科学严谨，又具有临床适用性，为提高儿童烧伤患者的医疗护理质量提供了循证基础。

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Article ID: 4737

Thyroid Dysfunction and Cardiovascular Risk—— Epidemiological Links, Mechanistic Pathways, and Clinical Management Strategies

by Danyao Zhang, Yuelei Wu, Haining Xi

Psycho-Oncologie , Vol.19, No.1s, 2025;

甲状腺功能异常（甲状腺功能亢进症/甲状腺功能减退症）显著增加心血管疾病的风险，并且相关性是人群异质性的（高龄、女性围绝经期、碘状况的地理差异）。流行病学研究表明，亚临床甲状腺功能亢进症使心房颤动的风险增加 4.5 倍，冠状动脉事件的风险增加 3.4 倍，尤其是在老年人和糖尿病患者中，亚临床甲状腺功能减退症 （TSH ≥7 mIU/L） 显着加速冠状动脉钙化的进展 （年化率增加 37.6%），并与血脂异常和心包积液有关。核心机制涉及甲状腺激素受体 （TRα1/TRβ1） 介导的心肌重塑 （MYH6/7 、 SERCA2a 等基因的调节，以及 HCN4 和 Cx43 等离子通道功能的调节）、代谢-氧化应激轴损伤 （SREBP-2/LXRs 失调、eNOS 解偶联和 NLRP3 炎症囊泡激活）和神经内分泌-血流动力学相互作用调节 （交感神经过度激活/ANP 抵抗）。临床管理强调特定心血管疾病（例如心力衰竭、心房颤动）患者的甲状腺功能筛查 （TSH/FT4），甲状腺功能亢进症（抗甲状腺药、β 受体阻滞剂）和甲状腺功能减退症（左旋甲状腺素滴定至 0.5-2.0 mIU/L）治疗方案的个体化，以及通过多学科合作途径和长期监测优化心血管结局。未来的重点需要放在亚临床疾病干预阈值精度和新型靶向药物 （例如 STRM） 的开发上。

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Article ID: 4690

Intraoperative Nursing Coordination in Hemostasis Management for Liver Tumor Resection

by Yaqian Lai, Haiwei Zhang, Ying Ye, Qiqiq Li

Psycho-Oncologie , Vol.19, No.1s, 2025;

[摘要]目标： 探讨护理协调在肝肿瘤切除术中止血管理中的作用。 方法： 2024 年 6 月至 2025 年 5 月期间接受肝肿瘤切除术的 86 例患者被随机分配到常规护理组 （n=43） 或护理协调组 （n=43） 和协调组 （ n =43）。手术期间分别应用常规护理和护理协调方案。比较两组手术指标 （手术时间、术中出血量、输血量）、凝血功能指标 （APTT、PT、FIB）、应激激素水平 （NE、Cor） 和并发症发生率 （出血、感染、肝衰竭）。 结果： 与常规组相比，协调组手术时间明显缩短，术中出血量减少，输血量减少 （P<0.05）。术后 24 h 时，协调组 PT 和 APTT 低于常规组，而 FIB 和 PLT 高于常规组， P <0.05。术后 24 h 协调组肾上腺素、去甲肾上腺素水平低于常规组 P <0.05。协调组并发症发生率低于常规组， P <0.05。 结论： 肝肿瘤切除过程中的护理协调模式具有良好的实施效果，可减少手术时间、术中失血量和输血量，提高患者的凝血功能指标，缓解应激反应，减少并发症，值得推广。

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Article ID: 4739

Analysis of CEP55 pan cancer immune and prognostic based on TCGA and GTEx databases

by Xiulian Xu, Pan Wang, Qijun Lv, Hailin Gan, Yiming Huang, Zhiheng Liu

Psycho-Oncologie , Vol.19, No.1s, 2025;

Overview Background The CEP55 encoded product is a centrosome protein.Participate in the development of the cranioskeletal system，Establish protein localizationand intermediate separation。Acting on the upstream or internal division of mitotic cells。CEP55 can affect the prognosis of various tumor types through multiple pathways。We evaluated the role of CEP55 using pan cancer data from the Cancer Genome Atlas (TCGA) and Genotyping Tissue Expression (GTEx) projects.   Method The potential role of CEP55 in different tumors was explored based on the Cancer Genome Atlas (TCGA) and Genotyping Tissue Expression (GTEx) datasets.CEP55 related expression differences, tumor mutation burden (TMB), microsatellite instability (MSI), MATH, clinical staging and gene expression, immune cell analysis (xCELL, CIBERSORT, Timer), gene expression prognosis, etc.Our research findings indicate that CEP55 affects the prognosis of cancer patients, and its role varies among different types of cancer。In some cases, elevated CEP55 gene expression is detrimental to survival, while the opposite is true in other tumor types.     Result CEP55 在各种肿瘤组织和癌症邻近的正常组织中表达存在差异。CEP55 与 TMB 和 MIS 等常见免疫治疗靶点相关，开发与 CEP55 相关的药物，具有通过 TMB 和 MSI 免疫靶点治疗相关肿瘤的潜力。CEP55 与肿瘤的临床分期相关，可作为临床肿瘤不同阶段调整治疗方案的依据。CEP55 在各种免疫细胞分析中显示出显著的相关性，表明 CEP55 广泛影响肿瘤免疫细胞，进而可能影响各种肿瘤的免疫调节，并可能参与多种肿瘤免疫微环境的调节，有可能作为潜在的免疫治疗靶点。CEP55 可能是一个潜在的新治疗靶点。   结论 CEP55 的表达在不同肿瘤之间有所不同，并且与各种肿瘤的临床分期相关。它可能参与多种肿瘤的免疫调节，并可能作为潜在的治疗靶点。

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Article ID: 4740

To assess the effectiveness of DAPT adherence on all-cause mortality among post-PCI patients and explore the potential determinants of DAPT adherence

by Qiaoling Ye, Hongxing Wang, Jiamiao Hu, Yinv Shi

Psycho-Oncologie , Vol.19, No.1s, 2025;

Abstract 背景： 坚持双重抗血小板治疗 （DAPT） 对于预防急性冠状动脉综合征 （ACS） 患者在经皮冠状动脉介入治疗 （PCI） 后的不良结局至关重要。尽管它很重要，但依从率会随着时间的推移而显着下降，并且有限的研究探索了依从性的动态轨迹及其预测因子。 目的： 分析 ACS 患者 PCI 后 12 个月内 DAPT 依从性的动态轨迹，确定依从性的预测因子，并评估数字出院后管理平台的影响。 方法： 这项纵向观察性研究包括 100 例接受 PCI 的 ACS 患者。使用数字管理平台在出院后 1 、 3 、 6 、 9 和 12 个月评估 DAPT 依从性。潜在变量增长模型确定了依从性轨迹，Logistic 回归分析了预测因子。比较依从性组之间的临床结局。 结果： 研究表明，依从性从 1 个月时的 88% 下降到 60 个月时的 12%。确定了三个依从性轨迹：独立：55% 始终坚持饮食方案，30% 是缓慢恶化者，其余 15% 是快速恶化者。对药物依从性感知障碍的多变量 logistic 回归检查显示，吸烟 （OR = 2.18;p = 0.001）、焦虑 （OR = 3.41;p = 0.000）、家庭支持少 （OR = 0.43;p = 0.000） 和 65 >岁 （OR = 1.12;p = 0.03） 与除了缺乏知识外，健忘 （40%）、副作用 （25%） 和成本 （20%） 导致健忘。在这些患者中，不依从性与主要不良心脏事件 （70% VS 12%;p < 0.01）、死亡率 （30% VS 5%;p < 0.01） 和再住院 （50% VS 8%;p < 0.01） 水平显著升高有关。该平台提高了 6 个月时的依从性 （76% vs. 70%;p = 0.04）、患者满意度 （92% vs. 78%;p < 0.01） 和随访完成率 （95% vs. 85%;p = 0.02）。 结论： ACS 后和接受 PCI 的患者对 DAPT 的依从性较差，患者在人口统计学、心理和社会预测因子方面有所不同，随着时间的推移表现出不同的趋势。值得注意的是使用数字出院后管理系统在简化实践方面的患者效用和有效性。综上所述，这些结果揭示了制定个性化策略以促进药物依从性及其目标的必要性。

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Article ID: 4759

Correlation Between Inflammatory Biomarkers and Psychological Resilience in Patients With Spinal Metastatic Tumors

by Jinguo Chen, Guoxian Chen, Guosong Xu, Weiting Lin, Yongda Yue

Psycho-Oncologie , Vol.19, No.1s, 2025;

脊柱转移性肿瘤 （SMT） 通常伴有剧烈疼痛和明显的炎症反应，这会对患者的生理和情绪恢复产生不利影响。心理弹性被认为在患者如何应对与这种情况相关的身体和情绪压力方面发挥着关键作用。本研究旨在探讨脊柱转移性肿瘤患者炎症生物标志物与心理弹性之间的关系。进行了一项涉及 128 名患者的前瞻性观察研究，从他们那里采集血样以评估炎症生物标志物，如 IL-6 、 TNF-α 和 CRP。使用 CD-RISC 、 HADS 和 PCS 量表进行心理评估。结果显示炎症标志物与心理弹性评分呈负相关。ELISA 和 qPCR 结果显示低恢复力组炎症水平较高，而 western blot 分析显示 IL-6 和 TNF-α 表达显著升高，表明与情绪困扰相关的慢性炎症状态。这些发现表明，炎症可能通过生理-心理途径影响情绪调节和心理适应能力，突出了炎症和脊柱转移性肿瘤患者心理弹性的相互关联性。

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Article ID: 4762

Bisphosphonate-related atypical femoral fracture: a case report and literature review

by Zhen Gu, Zhiwei Zhang

Psycho-Oncologie , Vol.19, No.1s, 2025;

双膦酸盐 （bisphosphonates，BPs） 一直是治疗骨质疏松症 （osteoporosis，O 和 P） 的金标准。然而，长期使用 BPs 与 1 种罕见并发症 - 非典型股骨骨折 （非典型股骨骨折，AFF） 有关。本文旨在介绍一例长期使用双膦酸盐治疗骨质疏松后不完全性非典型股骨骨折的临床病例，并对相关文献进行回顾。

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Article ID: 4781

Epidemiological characteristics and etiological factors of primary hypertension in the community population

by Xiangquan Chen

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的： 了解社区人群原发性高血压的流行病学特征和病因，为制定有针对性的高血压预防策略提供科学依据。方法： 从 2024 年 2 月到 2025 年 3 月，对 290 名 18 岁及以上的永久居民进行了横断面调查。收集人口统计数据、生活方式和病史，并进行标准化血压测量。采用 SPSS26.0 软件进行单因素分析和多因素 logistic 回归。结果： 社区原发性高血压患病率为 32.41% （94/290）。40-59 岁年龄组 （38.46%） 和 ≥60 岁年龄组 （56.67%） 的患病率显著高于 18-39 岁年龄组的 13.79% （P<0.01）。男性患病率 （38.71%） 高于女性患病率 （27.27%），差异有统计学意义 （P<0.05）。多因素logistic回归分析结果显示，年龄（OR=1.82,95%CI：[1.23-2.70]）、男性（OR=1.95,95%CI：1.12-3.40）、BMI≥28kg/m²（OR=2.31,95%CI：1.35-3.94）、高血压家族史（OR=3.14,95%CI：1.76-5.61）、高盐饮食（OR=2.08,95%CI：1.21-3.58）、缺乏运动（OR=1.89,95%CI：1.09-3.28）、饮酒（OR=1.77,95%CI：1.02-3.08）、高心理应激（OR=2.25,95%CI：1.30-3.91）是原发性高血压的独立危险因素。该社区的原发性高血压患病率相对较高，这受多种因素的影响。应实施有针对性的预防和控制措施，以减轻疾病负担。

Featured Article

Article ID: 4799

Nrf2/HO-1/NQO1 Pathway-Mediated Regulation of Mitophagy in Renal Ischemia-Reperfusion Injury

by Zexin wang, Jinghui Fan, Xing Li, Zelin Guo, Fan Cheng

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的： 探讨核因子红细胞 2 相关因子 2 （Nrf2）/血红素加氧酶-1 （HO-1）/NAD（P）H 醌氧化还原酶 1 （NQO1） 信号通路介导线粒体自噬以防止肾缺血再灌注损伤 （RIRI） 的机制。 方法： 将 40 只大鼠随机分为 4 组。将 10 只大鼠分配到对照组，给予生理盐水。其余 30 只大鼠建立 RIRI 模型，其中 28 只大鼠成功建模。然后将这些分为三组：模型组 （n = 10），接受生理盐水;激动剂组 （n = 9），接受 Nrf2 激动剂;抑制剂组 （n = 9），接受 Nrf2 抑制剂。干预 14 d 后，检测肾功能 （血尿素氮 （BUN） 和血清肌酐 （Scr））、氧化应激指标 （丙二醛 （MDA） 和超氧化物歧化酶 （SOD））、线粒体自噬相关蛋白 （BCL-2/BNIP3/LC3-II） 表达水平以及 Nrf2 、 HO-1 和 NQO1 表达水平。 结果： 与对照组相比，模型组、激动剂组和抑制剂组 BUN 、 Scr 和 MDA 水平显著升高，而 SOD 水平、线粒体自噬相关蛋白 （Bnip3 和 LC3-II） 表达以及 Nrf2 、 HO-1 和 NQO1 的 mRNA 和蛋白表达水平显著降低 （P < 0.05）。与模型组相比，激动剂组 BUN 、 Scr 和 MDA 水平显著降低，SOD 水平、 BNIP3 和 LC3-II 蛋白表达以及 Nrf2 、 HO-1 和 NQO1 的 mRNA 和蛋白表达显著升高 （P < 0.05）;而抑制剂组显示 BUN 、 Scr 和 MDA 水平升高，SOD 水平降低，BNIP3 和 LC3-II 蛋白表达，以及 Nrf2 、 HO-1 和 NQO1 mRNA 和蛋白水平降低 （P < 0.05）。与激动剂组相比，抑制剂组的 BUN 、 Scr 和 MDA 水平显著升高，SOD 水平显著降低，Bnip3 和 LC3-II 蛋白表达，Nrf2 、 HO-1 和 NQO1 mRNA 和蛋白表达降低 （P < 0.05）。 结论： 激活 Nrf2/HO-1/NQO1 信号通路可增强线粒体自噬，改善肾功能，并通过 RIRI 减轻氧化应激。

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Article ID: 4801

Efficacy analysis of Zhang's superconducting agreement formula 3 ultrasonic drug penetration combined with shoulder joint cavity perfusion and manual release in the treatment of frozen shoulder of qi stagnation and blood stasis type

by Jie Xiang, Fengfan Sun, Xiaofang Zhang

Psycho-Oncologie , Vol.19, No.1s, 2025;

目的： 探讨张氏超导方3超声药物穿透联合肩关节腔灌注手法松解治疗气滞血瘀型肩周炎的效果。方法： 选取 2024 年 1 月至 2024年12月我院收治的 74 例气滞血瘀型肩周炎患者为研究对象，按随机数字表法分为对照组和联合组，每组 37 例。对照组采用关节腔灌注和手法治疗，联合组在对照组基础上采用张氏超导方案 3 超声药物渗透治疗。比较两组疗效、 Constant-Murley 评分、 VAS 评分、美国肩肘手术评分 （ASES） 和关节活动度。结果： 联合组有效率高于对照组 （P < 0.05）。两组治疗前 Constant-Murley 评分差异无统计学意义 （P>0.05）。治疗后，联合组的疼痛、ADL、肌力和关节活动评分均高于对照组 （P < 0.05）。两组治疗前 VAS 和 ASES 评分差异无统计学意义 （P>0.05）。治疗后，联合组ASES评分高于对照组，VAS评分低于对照组（P < 0.05）。治疗前，两组患者的关节活动度差异无统计学意义 （P>0.05）。治疗后，联合组的屈、伸、外展、内旋、外旋活动均高于对照组 （P < 0.05）。结论： 张氏超导协议 3 号超声药物渗透联合肩关节腔灌注手法释放治疗肩周炎气瘀血瘀可缓解疼痛，改善临床症状，提高关节活动度和治疗效果。

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Analysis of the facilitating effect of medication on postoperative recovery of elderly patients with total cystectomy in situ urinary diversion based on CGA comprehensive nursing model

by Zelin Guo, You wang, Ting Yang, Zhongxiang Cai, Xing Li, Fan Cheng

Psycho-Oncologie , Vol.19, No.1s, 2025;

本文的目的是探讨基于老年综合评估 （CGA） 的术后恢复方法对接受全膀胱切除术原位尿流改道术患者的有效性。将 CGA 引入老年全膀胱切除术原位尿流改道术患者、编号膀胱癌患者的术后恢复过程，并根据组间基本特征匹配进行分组。对照组采用常规膀胱癌保健与咨询服务方案，观察组采用常规膀胱癌保健与咨询服务+CGA护理方案。采用世界卫生组织生活质量测量量表 （WHOQOL-100） 、功能状态量表 （KPS） 和日常生活活动量表 （ADL） 评估两组患者术后 6 个月和术前 6 个月的膀胱功能、并发症发生率、生存质量、身体健康和日常生活能力， 分别。观察组患者起床时间、通气时间、进食时间均低于对照组，P < 0.05。各种常见术后并发症的数量减少，发生率低于对照组。观察组患者经CGA护理后能够积极面对疾病，生成总质量为73.85±16.85，显著高于对照组的66.14±18.02，两者均具有统计学意义。

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Analysis of the potential dimensions of guilt feelings among family caregivers of elderly patients with multiple chronic conditions and their influencing factors

by 高华 王, Xiaojie Ma, Ruihan Wu, Lili Zhang, Xiangying Shen, Jiaojiao Wu, Zhen Luo, Xinmei Wang, Doudou Lin

Psycho-Oncologie , Vol.19, No.1s, 2025;

患有多种慢性病的老年患者是老年人口中同时患有各种慢性病的个体。这种情况不仅影响了他们的生活质量，也给他们的家庭和社会带来了巨大的经济负担。针对家庭照护者在照护过程中可能经历的心理压力，本研究旨在探讨多种慢性病老年患者家庭照护者内疚感的异质性及其影响因素。采用计划于2024年6月至2025年6月进行的横断面调查设计，选择在武汉某三甲医院接受治疗的多种慢性病老年患者的家庭照护者，采用标准化量表评估其内疚感。将采用潜在概况分析（LPA）来识别具有不同内疚感水平的潜在亚组，并进行多元logistic回归分析以探索影响因素。研究结果有望表明，家庭照顾者的内疚感可分为3种典型的潜在特征，与患者并存疾病数量、自我调节能力、家庭照顾态度、创伤后应激反应显著相关。具体来说，更多的共存疾病、更短的护理时间以及更强的创伤事件影响与更明显的护理人员的内疚感相关;而更强的家庭支持、对自我调节疲劳的抵抗力更强以及自我分化水平越高，导致照顾者的内疚感降低。这些发现强调了加强家庭支持和增强照护者自我调节能力的重要性，揭示了患有多种慢性病的老年患者家庭照护者内疚感的异质性，为未来有针对性的心理干预提供了依据。因此，未来的研究应整合临床和社会心理资源，以提高护理质量，并制定增强家庭福祉的策略。