The Impact of Chronic Obstructive Pulmonary Disease on Respiratory Physiology, Chemotherapy Tolerance, and Psychological Adaptation in Oncology Patients: A Multidimensional Analysis
Abstract
Abstract
Chronic obstructive pulmonary disease (COPD) exacerbates clinical outcomes in oncology patients through impaired respiratory mechanics, chemoresistance, and psychological distress. This review examines: (1) COPD-mediated alterations in lung function and gas exchange during cancer therapy; (2) Mechanistic links between COPD inflammation and chemotherapeutic efficacy; (3) Psychosocial interventions improving treatment adherence and quality of life. Data from randomized controlled trials (RCTs) and longitudinal cohort studies demonstrate that integrated cognitive-behavioral therapy (CBT) reduces anxiety by 35% compared to standard care (95% CI: 28-42%, p<0.001). (5) Comprehensive management strategies combining pulmonary rehabilitation and psychotherapy show 22% higher 5-year survival rates in COPD-positive cancer patients (HR: 0.78, 95% CI: 0.65-0.93). (7)
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