Analysis of clinical status and risk factors of blood infection of Klebsiella pneumoniae in hospital

Article ID: 4895

Abstract

Objective To analyze the clinical status and risk factors of patients with blood infection caused by Klebsiella pneumoniae.Methods 110 patients with blood infection in clinical departments of our hospital from May 2022 to May 2023 were reviewed, and 130 strains of Enterobacteriaceae bacteria were isolated from blood flow samples,110 of which were Klebsiella pneumoniae (cKP).Staphylococcus aureus ATCC29213, Streptococcus pneumoniae ATCC49619, Escherichia coli ATCC25922,Enterococcus faecalis ATCC29212 and Pseudomonas aeruginosa ATCC27853 were used as quality control strains to analyze the distribution, clinical characteristics, risk factors and drug resistance of Klebsiella pneumoniae.Results Among 130 strains of Enterobacteriaceae,110 strains of Klebsiella pneumoniae (cKP)were mainly distributed in hematology, surgery and other departments. Compared with other departments, the number of Klebsiella pneumoniae in department of hematology and surgery was significantly increased, and the difference was statistically significant (P<0.05).There was no significant difference in the distribution of Klebsiella pneumoniae among other departments (P>0.05). A total of 110 cases of Klebsiella pneumoniae infection were included in this study, of which 60.91% were male, 59.09% were over 60 years old, 33.64% had blood infection as the primary focus, and the infection method was mainly hospital-acquired, accounting for 69.09%. The results of single factor analysis showed that the risk factors of Klebsiella pneumoniae infection were primary lesion, treatment, acquisition, underlying disease,urinary tract intubation and blood type. Multivariate Logistic regression analysis showed that nosocomial infection,liver disease,diabetes,urinary tract intubation and blood type were independent risk factors for bloodstream infection of Klebsiella pneumoniae.The resistance rate of Klebsiella pneumoniae to piperacillin was the highest (39.92%). The resistance rate of the first to fourth generation of cephalosporins was 6.21% to 41.25%, of which the lowest resistance rate of cefotetan was 6.21%, and the highest resistance rate of cephalosporin was 41.25%. 42 ESBLs strains were detected among 110 Klebsiella pneumoniae strains, and the positive rate was 38.18%.Conclusion Physicians should pay special attention to the infection of Klebsiella hyperpneumoniae caused by diabetes,blood type,urinary tract intubation, and pay attention to the diagnosis, treatment and infection control.