Correlation Between Inflammatory Biomarkers and Psychological Resilience in Patients With Spinal Metastatic Tumors

Jinguo Chen; Guoxian Chen; Guosong Xu; Weiting Lin; Yongda Yue

doi:10.18282/po4759

Jinguo Chen Department of Orthopaedics, The First Hospital of Putian City
Guoxian Chen ^* Department of Orthopaedics, The First Hospital of Putian City, Putian, Fujian, China
Guosong Xu Department of Orthopaedics, The First Hospital of Putian City
Weiting Lin Department of Orthopaedics, The First Hospital of Putian City
Yongda Yue Department of Orthopaedics, The First Hospital of Putian City

Article ID: 4759

Abstract

Spinal metastatic tumors (SMT) are often accompanied by severe
pain and significant inflammatory responses, which can adversely affect both the
physiological and emotional recovery of patients. Psychological resilience is believed to play a key role in how patients cope with both physical and emotional
stress associated with this condition. This study aimed to explore the relationship between inflammatory biomarkers and psychological resilience in patients
with spinal metastatic tumors. A prospective observational study was conducted
involving 128 patients, from whom blood samples were collected to assess inflammatory biomarkers such as IL-6, TNF-α and CRP. Psychological assessments were performed using the CD-RISC, HADS, and PCS scales. The results
revealed a negative correlation between inflammatory markers and psychological
resilience scores. ELISA and qPCR results demonstrated higher levels of inflammation in the low resilience group, while western blot analysis revealed significantly elevated expression of IL-6 and TNF-α, indicating a chronic inflammatory
state associated with emotional distress. These findings suggest that inflammation
may affect emotional regulation and psychological adaptability through a physiological-psychological pathway, highlighting the interconnectedness of inflammation and psychological resilience in patients with spinal metastatic tumors.