Analysis of Clinical Characteristics and Risk Factors for Recurrence after Hysteroscopic Resection in Endometrial Cancer Patients

Article ID: 4726

Abstract

Objective To investigate changes in clinical characteristics and risk factors for recurrence after hysteroscopic resection in endometrial cancer patients.Methods This study enrolled 108 endometrial cancer patients who underwent hysteroscopic resection at our hospital from January 2022 to June 2023. All participants received two-year postoperative follow-up through outpatient visits and telephone interviews, with subsequent stratification into recurrence and non-recurrence groups based on documented recurrence status. The postoperative recurrence was recorded, and the patients were divided into the recurrence group and the non-recurrence group based on whether they had a recurrence. General information, laboratory tumor marker indicators, pathological features and other relevant data were collected through the hospital's electronic medical record system. The related risk factors affecting the recurrence of endometrial cancer patients after hysteroscopic electroresection were further analyzed.Results Among the 108 patients with endometrial cancer included in this study, adenocarcinoma was the most common pathological type, accounting for 69.44%, and most of them were at stage I-II (78.65%) with early-stage lesions. After a 2-year follow-up after hysteroscopic electroresection, 24 cases (22.22%) recurred and 84 cases (77.78%) did not. There were statistically significant differences in serum CA125 levels, histopathological grades, lymph node metastasis, depth of myometrial invasion, tumor diameter, para-aortic lymph node dissection, and postoperative hormone therapy between the recurrence group and the non-recurrence group (P <0.05). The results of multiple logistic regression analysis showed that serum CA125, histopathological grade G3, lymph node metastasis, myometrial invasion depth≥1/2, tumor diameter > 2 cm, no para-aortic lymph node dissection, and no postoperative hormone therapy were risk factors for recurrence after hysteroscopic electroresection in patients with endometrial cancer (OR>1, P<0.05). Conclusion: The recurrence rate after hysteroscopic electroresection for endometrial cancer is relatively high and is related to factors such as serum CA125 levels, histopathological grades, lymph node metastasis, depth of myometrial invasion, and tumor diameter.