A Comparative Transcriptomic Analysis of Pathogenic Mechanisms between Papillary Thyroid Carcinoma and Hashimoto's Thyroiditis

Xuelu Xu; Yuqing Ma; Jie Yang; Weibin Fan; Wenxia Wang; Zhizheng Xu

doi:10.18282/po4703

Xuelu Xu Changxing County People's Hospital，Pathology Department
Yuqing Ma Changxing County People's Hospital，Pathology Department
Jie Yang ^* Changxing County People's Hospital，Pathology Department
Weibin Fan Changxing County People's Hospital，Pharmacy Department
Wenxia Wang Changxing County People's Hospital，General Surgery Department
Zhizheng Xu Changxing County People's Hospital，Oncology and Hematology Department

Article ID: 4703

Keywords: Papillary thyroid carcinoma; Hashimoto’s thyroiditis; Expression Middle Road, Changxing County, Huzhou City, Zhejiang Province, China. 313100*These authors contrbuted equally to this workprofile comparative analysis

Abstract

Papillary thyroid carcinoma (PTC) and Hashimoto’s thyroiditis (HT) appear antagonistic but often occur simultaneously. This study integrates four GEO datasets to compare gene expression differences among PTC, HT, PTC_ HT, and control thyroid tissues (Control), revealing similarities and differences in gene expression. Results show significant differences in 202 genes among the three conditions, with consistent upregulation/downregulation trends, primarily involving inflammation and chemokines (e.g., CXCL8, CXCL9, CXCL10, IL8). Cells in PTC and HT are in a state of chronic inflammatory activation and are unresponsive to p53 and FAS-induced apoptotic signals. Analysis of differentially expressed genes between PTC and HT reveals that several extracellular matrix pathway genes (e.g., FN1, LAMB1, LAMC1) have opposite expression trends in the two diseases, and the FN1-DUSP6-ETV5-NFATC1/3 signaling axis may drive phenotypic heterogeneity by regulating T cell immune responses. These findings provide new insights into the molecular mechanisms and interrelationship of PTC and HT.